Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMIWSAVF LNSLFNQEVQ IPLTESYCGP CPKNWICYKN NCYQFFDESK NWYESQASCM SQNASLLKVY SKEDQDLLKL VKSYHWMGLV HIPTNGSWQW EDGSILSPNL LTIIEMQKGD CALYASSFKG YIENCSTPNT YICMQRTV
    • Molecular weight

      19 kDa including tags
    • Amino acids

      73 to 216
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab137140 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 90 % SDS-PAGE.

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • CD314
    • CD314 antigen
    • D12S2489E
    • Killer cell lectin like receptor subfamily K member 1
    • Killer cell lectin-like receptor subfamily K member 1
    • KLR
    • KLRC4 KLRK1 readthrough
    • KLRK1
    • NK cell receptor D
    • NK lectin-like receptor
    • NKG2 D activating NK receptor
    • NKG2 D type II integral membrane protein
    • NKG2-D
    • NKG2-D type II integral membrane protein
    • NKG2-D-activating NK receptor
    • Nkg2d
    • NKG2D_HUMAN
    • NKLLR
    • NKR P2
    • Nkrp2
    see all
  • Function

    Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.
  • Tissue specificity

    Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells. Expressed in interferon-producing killer dendritic cells (IKDCs).
  • Sequence similarities

    Contains 1 C-type lectin domain.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of 3 µg ab137140.

References

ab137140 has not yet been referenced specifically in any publications.

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