Description

  • Product name

    Recombinant Human NKIRAS2 protein
  • Purity

    > 90 % SDS-PAGE.
    ab124599 is purified by using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMGKSCK VVVCGQASVG KTSILEQLLY GNHVVGSEMI ETQEDIYVGS IETDRGVREQ VRFYDTRGLR DGAELPRHCF SCTDGYVLVY STDSRESFQR VELLKKEIDK SKDKKEVTIV VLGNKCDLQE QRRVDPDVAQ HWAKSEKVKL WEVSVADRRS LLEPFVYLAS KMTQPQSKSA FPLSRKNKGS GSLDG
    • Predicted molecular weight

      24 kDa including tags
    • Amino acids

      1 to 191
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab124599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names

    • DKFZP434N1526
    • I kappa B interacting Ras like protein 2
    • I-kappa-B-interacting Ras-like protein 2
    • Kappa B Ras protein 2
    • Kappa B-Ras protein 2
    • KappaB Ras2
    • KappaB-Ras2
    • KBRAS 2
    • KBRAS2
    • KBRS2_HUMAN
    • MGC74742
    • NF kappa B inhibitor interacting Ras like protein 2
    • NF-kappa-B inhibitor-interacting Ras-like protein 2
    • NFKB inhibitor interacting Ras like 2
    • NFKB inhibitor interacting Ras like protein 2
    • NKIRAS 2
    • NKIRAS2
    see all
  • Function

    Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
  • Tissue specificity

    Widely expressed.
  • Sequence similarities

    Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
  • Domain

    In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab124599 (3µg).

References

ab124599 has not yet been referenced specifically in any publications.

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