Recombinant Human Noxa protein (ab152618)
Key features and details
- Expression system: Wheat germ
- Suitable for: SDS-PAGE, WB, ELISA
Description
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Product name
Recombinant Human Noxa protein -
Expression system
Wheat germ -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MPGKKARKNAQPSPARAPAGPAGTAGTARDQAGFAIGMQLRFTRGKKLLS SSLSSSPLALPRGHEEQVQVAGSRVCYSTQEIWRQTELPAETSESDIQTL LLRNLTASKTCMRGLLQKSFLRRCTFHQFEERLHCN -
Predicted molecular weight
41 kDa including tags -
Amino acids
1 to 136
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Specifications
Our Abpromise guarantee covers the use of ab152618 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
Western blot
ELISA
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Form
Liquid -
Additional notes
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- Adult T cell leukemia derived PMA responsive
- APR
- APR_HUMAN
see all -
Function
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. -
Tissue specificity
Highly expressed in adult T-cell leukemia cell line. -
Sequence similarities
Belongs to the PMAIP1 family. -
Domain
The BH3 motif is essential for pro-apoptotic activity. -
Cellular localization
Mitochondrion. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (0)
ab152618 has not yet been referenced specifically in any publications.