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    recombinant-human-noxa2p67phox-protein-ab117065.pdf

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Recombinant Human NOXA2/p67phox protein (ab117065)

  • Datasheet
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SDS-PAGE - Recombinant Human NOXA2/p67phox protein (ab117065)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: WB, SDS-PAGE, ELISA

    Description

    • Product name

      Recombinant Human NOXA2/p67phox protein
    • Expression system

      Wheat germ
    • Accession

      P19878
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTIL KNMTEAEKAFTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQ LRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKKEEWKKAEEQLALATSM KSEPRHSKIDKAMECVWKQKLYEPVVIPVGRLFRPNERQVAQLAKKDYLG KATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFG FVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELR IHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPM PYTLKVHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEQTKLSYRPRDSN ELVPLSEDSMKDAWGQVKNYCLTLWCENTVGDQGFPDEPKESEKADANNQ TTEPQLKKGSQVEALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGECK GKVGIFPKVFVEDCATTDLESTRREV
      • Predicted molecular weight

        84 kDa including tags
      • Amino acids

        1 to 526

    Associated products

    • Related Products

      • Anti-NOXA2/p67phox antibody [EPR5064] (ab109366)
      • Anti-NOXA2/p67phox antibody [EPR5065] (ab109523)

    Specifications

    Our Abpromise guarantee covers the use of ab117065 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Western blot

      SDS-PAGE

      ELISA

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.3% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • 67 kDa neutrophil oxidase factor
      • Chronic granulomatous disease autosomal 2
      • FLJ93058
      • NADPH oxidase activator 2
      • NCF-2
      • Ncf2
      • NCF2_HUMAN
      • Neutrophil cytosol factor 2
      • Neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)
      • Neutrophil NADPH oxidase factor 2
      • NOXA2
      • P67 PHOX
      • p67-phox
      • p67phox
      see all
    • Function

      NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
    • Involvement in disease

      Defects in NCF2 are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2) [MIM:233710]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
    • Sequence similarities

      Belongs to the NCF2/NOXA1 family.
      Contains 1 OPR domain.
      Contains 2 SH3 domains.
      Contains 3 TPR repeats.
    • Cellular localization

      Cytoplasm.
    • Target information above from: UniProt accession P19878 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human NOXA2/p67phox protein (ab117065)
      SDS-PAGE - Recombinant Human NOXA2/p67phox protein (ab117065)
      12.5% SDS-PAGE showing ab117065 at approximately 83.86 kDa.
      Stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab117065? Please let us know so that we can cite the reference in this datasheet.

    ab117065 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Question

    Sehr geehrte Damen und Herren, wir möchten in unserer Arbeitsgruppe beginnen, mit der NADPH-oxidase in Makrophagen (Rattenmakrophagen NR8383, ev. auch humane Monozyten/Makrophagen U937) zu arbeiten und sind auf der Suche nach Antikörpern gegen ihre Bestandteile (p47PHOX, p40PHOX, p67PHOX, P22PHOX, gp91PHOX, Rac1/2, Rho-GDI, …), sowie (falls möglich) die Einzelkomponenten selber (für die Arbeit im zellfreien System). Können Sie uns weiterhelfen? Über ein Angebot würden wir uns freuen.

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    Abcam community

    Verified customer

    Asked on Dec 09 2011

    Answer

    Vielen Dank für Ihre Anfrage. Gegen die genannten NADPH-Oxidase-Komponenten haben wir folgende Antikörper bzw. Proteine in unserem Katalog: Click here (or use the following: https://www.abcam.com/NOXA2p67phox-antibody-EPR5064-ab109366.html). Click here (or use the following: https://www.abcam.com/NOX2gp91phox-antibody-ab80508.html). Click here (or use the following: https://www.abcam.com/Rac1-antibody-23A8-ab33186.html). Click here (or use the following: https://www.abcam.com/RAC2-antibody-ab2244.html). Click here (or use the following: https://www.abcam.com/RhoGDI-antibody-OTI1F2-ab118159.html). Click here (or use the following: https://www.abcam.com/Cytochrome-b245-Light-Chainp22-phox-antibody-ab75941.html). Click here (or use the following: https://www.abcam.com/p40-phox-antibody-ab115855.html). Click here (or use the following: https://www.abcam.com/p40-phox-phospho-T154-antibody-ab59355.html). Click here (or use the following: https://www.abcam.com/NCF1p47-phox-phospho-S328-antibody-ab111855.html). Click here (or use the following: https://www.abcam.com/NCF1p47-phox-antibody-ab795.html). Click here (or use the following: https://www.abcam.com/Human-NCF4-full-length-protein-ab88031.html). Click here (or use the following: https://www.abcam.com/Recombinant-Human-NCF1p47-phox-protein-ab98054.html). Click here (or use the following: https://www.abcam.com/Recombinant-Human-NOXA2p67phox-protein-ab117065.html). Click here (or use the following: https://www.abcam.com/Recombinant-Human-NOX2gp91phox-protein-ab114183.html). Click here (or use the following: https://www.abcam.com/Recombinant-Human-Rac1-protein-ab84657.html). Click here (or use the following: https://www.abcam.com/Human-Rac1-full-length-protein-ab40471.html). Click here (or use the following: https://www.abcam.com/Recombinant-Human-Rac1-protein-ab89246.html). Click here (or use the following: https://www.abcam.com/Recombinant-Human-Rac1-protein-ab82670.html). Click here (or use the following: https://www.abcam.com/Recombinant-Human-Rac1-protein-ab51014.html). Click here (or use the following: https://www.abcam.com/Recombinant-Human-RAC2-protein-ab84655.html). Click here (or use the following: https://www.abcam.com/Recombinant-Human-RAC2-protein-ab78684.html). Click here (or use the following: https://www.abcam.com/Recombinant-Human-RAC2-protein-ab87665.html). Vielleicht interessiert Sie in diesem Zusammenhang auch einer unserer Assaykits (NADP/NADPH): Click here (or use the following: https://www.abcam.com/NADPNADPH-Assay-Kit-ab65349.html). Wir geben alle getesteten Spezies und Anwendungen auf unseren Produktdatenblättern an und aktualisieren diese sobald wir neue Informationen erhalten. Falls sich herausstellt, dass der Antikörper nicht so funktioniert, wie auf dem Datenblatt beschrieben und Sie sich innerhalb von sechs Monaten mit Ihrem Problem an uns wenden, werden wir Ihnen gerne Vorschläge zur Optimierung Ihres Protokolls oder gegebenenfalls einen Ersatz oder eine Gutschrift schicken. Falls der Antikörper in einer bisher nicht getesteten Anwendung oder Spezies verwendet wird (z.B. für ab111855 oder ab115855), qualifizieren Sie sich für unser Testprogramm: Bei diesem Angebot bekommen Sie einen 100%igen Rabatt für eine zukünftige Bestellung, wenn Sie uns ein Abreview mit dem Testresultat zusenden. Die Bedingungen zu unserem 100% Abreview Rabatt können Sie unter dem folgenden Link nachlesen: https://www.abcam.com/collaborationdiscount. Falls Sie daran interessiert sind oder weitere Fragen haben, kontaktieren Sie bitte unseren wissenschaftlichen Dienst. Die oben genannten Antikörper sind nur eine Auswahl und wir haben noch weitere gegen die entsprechenden Zielproteine erhältlich, die für unterschiedliche Anwendungen getestet und garantiert sind. Bei einer detaillierteren Suche bzw. Beratung bin ich Ihnen gerne weiter behilflich. Gerne senden wir Ihnen auch gerne ein Angebot zu, sobald Sie eine konkrete Auswahl getroffen haben. Ich hoffe, diese Informationen helfen Ihnen weiter. Bitte zögern Sie nicht, sich wieder bei uns zu melden, falls Sie weitere Fragen haben.

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    Abcam Scientific Support

    Answered on Dec 09 2011

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