Description

  • Product name

    Recombinant Human NR5A2 / LRH1 protein
    See all NR5A2 / LRH1 proteins and peptides
  • Biological activity

    1 unit equals 1 nanogram of purified protein.
  • Expression system

    Baculovirus
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human

Specifications

Our Abpromise guarantee covers the use of ab82070 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Additional notes

    1 unit equals 1 nanogram of purified protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.75% Potassium chloride, 0.0154% DTT, 0.316% Tris HCl, 0.00584% EDTA, 20% Glycerol

General Info

  • Alternative names

    • Alpha-1-fetoprotein transcription factor
    • B1-binding factor
    • B1F
    • B1F2
    • CPF
    • CYP7A promoter-binding factor
    • FTF
    • FTZ F1
    • FTZ F1beta
    • FTZ-F1
    • FTZ-F1beta
    • hB1F
    • hB1F 2
    • hB1F-2
    • Hepatocytic transcription factor
    • Liver receptor homolog 1
    • LRH-1
    • LRH1
    • Nr5a2
    • NR5A2_HUMAN
    • Nuclear receptor subfamily 5 group A member 2
    see all
  • Function

    Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
  • Tissue specificity

    Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells.
  • Sequence similarities

    Belongs to the nuclear hormone receptor family. NR5 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt

References

ab82070 has not yet been referenced specifically in any publications.

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