Description

  • Product name

    Recombinant Human NSFL1C protein
  • Expression system

    Wheat germ
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MAAERQEALREFVAVTGAEEDRARFFLESAGWDLQIALASFYEDGGDEDI VTISQATPSSVSRGTAPSDNRVTSFRDLIHDQDEDEEEEEGQRFYAGGSE RSGQQIVGPPRKKSPNELVDDLFKGAKEHGAVAVERVTKSPGETSKPRPF AGGGYRLGAAPEEESAYVAGEKRQHSSQDVHVVLKLWKSGFSLDNGELRS YQDPSNAQFLESIRRGEVPAELRRLAHGGQVNLDMEDHRDEDFVKPKGAF KAFTGEGQKLGSTAPQVLSTSSPAQQAENEAKASSSILIDESEPTTNIQI RLADGGRLVQKFNHSHRISDIRLFIVDARPAMAATSFILMTTFPNKELAD ESQTLKEANLLNAVIVQRLT
    • Amino acids

      1 to 370
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab163284 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • DJ776F14.1
    • MGC3347
    • NSF1C_HUMAN
    • NSFL1 (p97) cofactor (p47)
    • NSFL1 cofactor p47
    • NSFL1C
    • OTTHUMP00000029972
    • OTTHUMP00000029974
    • p47
    • P47 protein
    • p97 cofactor p47
    • SHP1 homolog
    • UBX domain protein 2C
    • UBX domain-containing protein 2C
    • UBX1
    • UBXD10
    • UBXN2C
    see all
  • Function

    Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro).
  • Sequence similarities

    Belongs to the NSFL1C family.
    Contains 1 SEP domain.
    Contains 1 UBX domain.
  • Post-translational
    modifications

    Phosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the fragmentation of the Golgi stacks during mitosis.
  • Cellular localization

    Nucleus. Golgi apparatus > Golgi stack. Chromosome. Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks.
  • Information by UniProt

Images

  • ab163284 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab163284 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab163284.
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