Description

  • Product name

    Recombinant human NT-4 protein (Animal Free)
    See all NT-4 proteins and peptides
  • Biological activity

    The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found in the range of 20-50 ng/ml.

  • Purity

    > 98 % SDS-PAGE.
    ab217475 is greater than 98% pure as assessed by SDS-PAGE gel and HPLC analyses.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    Yes
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA
    • Predicted molecular weight

      14 kDa
    • Amino acids

      81 to 210
    • Additional sequence information

      Full length mature noncovalently linked homodimer protein

Specifications

Our Abpromise guarantee covers the use of ab217475 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    Functional Studies

    SDS-PAGE

  • Form

    Lyophilised
  • Additional notes

    Manufactured using all Animal-Free reagents.

    Previously labelled as Neurotrophin 4. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    For lot specific reconstitution information please contact our Scientific Support Team.

General Info

  • Alternative names

    • GLC10
    • GLC1O
    • Neurotrophic factor 4
    • Neurotrophic factor 5
    • Neurotrophin 4
    • Neurotrophin 4/5
    • Neurotrophin 5
    • Neurotrophin 5 (neurotrophin 4/5)
    • Neurotrophin-4
    • Neurotrophin-5
    • Neutrophic factor 4
    • Neutrophic factor 5
    • NT 4
    • NT 4/5
    • NT 5
    • NT-4
    • NT-5
    • NT4
    • NT4/5
    • NT4P
    • NT5
    • NTF4
    • NTF4_HUMAN
    • NTF5
    see all
  • Function

    Target-derived survival factor for peripheral sensory sympathetic neurons.
  • Tissue specificity

    Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
  • Involvement in disease

    Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:613100]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
  • Sequence similarities

    Belongs to the NGF-beta family.
  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab217475 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab217475.
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