Recombinant Human OASL protein (ab160131)

Our Abpromise guarantee covers the use of ab160131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- 2' 5' oligoadenylate synthetase like
- 2''-5''-OAS-related protein
- 2''-5''-OAS-RP
- 2''-5''-oligoadenylate synthase-like protein
- 2'-5' oligoadenylate synthetase-like 2
- 2'-5'-oligoadenylate synthetase-like
- 59 kDa 2' 5' oligoadenylate synthetase like protein
- 59 kDa 2''-5''-oligoadenylate synthase-like protein
- 59 kDa 2'-5'-oligoadenylate synthetase-like protein
- M1204
- Mmu-OASL
- OASL
- OASL_HUMAN
- Oasl2
- p59 OASL
- p59OASL
- THYROID HORMONE RECEPTOR INTERACTOR 14
- Thyroid receptor interacting protein 14
- Thyroid receptor-interacting protein 14
- TR-interacting protein 14
- TRIP-14
- TRIP14
see all
Function

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
Tissue specificity

Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.
Sequence similarities

Belongs to the 2-5A synthase family.
Contains 2 ubiquitin-like domains.
Domain

The ubiquitin-like domains are essential for its antiviral activity.
Cellular localization

Cytoplasm and Nucleus > nucleolus. Cytoplasm.
Target information above from: UniProt accession Q15646 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human OASL protein (ab160131)

ab160131 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ab160131 has not yet been referenced specifically in any publications.

Publishing research using ab160131? Please let us know so that we can cite the reference in this datasheet.

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