Recombinant Human OASL protein (ab160131)

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Description

  • Product name

    Recombinant Human OASL protein

  • Expression system

    Wheat germ

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MALMQELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQ GKRGLDQDVRVLKVVKVGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKH

    • Amino acids

      1 to 100

    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab160131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid

  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • 2' 5' oligoadenylate synthetase like
    • 2''-5''-OAS-related protein
    • 2''-5''-OAS-RP
    • 2''-5''-oligoadenylate synthase-like protein
    • 2'-5' oligoadenylate synthetase-like 2
    • 2'-5'-oligoadenylate synthetase-like
    • 59 kDa 2' 5' oligoadenylate synthetase like protein
    • 59 kDa 2''-5''-oligoadenylate synthase-like protein
    • 59 kDa 2'-5'-oligoadenylate synthetase-like protein
    • M1204
    • Mmu-OASL
    • OASL
    • OASL_HUMAN
    • Oasl2
    • p59 OASL
    • p59OASL
    • THYROID HORMONE RECEPTOR INTERACTOR 14
    • Thyroid receptor interacting protein 14
    • Thyroid receptor-interacting protein 14
    • TR-interacting protein 14
    • TRIP-14
    • TRIP14
    see all

  • Function

    Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.

  • Tissue specificity

    Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.

  • Sequence similarities

    Belongs to the 2-5A synthase family.
    Contains 2 ubiquitin-like domains.

  • Domain

    The ubiquitin-like domains are essential for its antiviral activity.

  • Cellular localization

    Cytoplasm and Nucleus > nucleolus. Cytoplasm.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human OASL protein (ab160131)
    SDS-PAGE - Recombinant Human OASL protein (ab160131)
    ab160131 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab160131 has not yet been referenced specifically in any publications.

Publishing research using ab160131? Please let us know so that we can cite the reference in this datasheet.

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