Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      22 kDa
    • Amino acids

      1 to 204
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127660 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 95 % Purified via His tag.
    Purity was determined to be >95% by SDS-PAGE.
  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with 150µl water.

General Info

  • Alternative names

    • FLJ13624
    • FLJ22833
    • hSSB2
    • MGC111163
    • Nabp1
    • Nucleic acid-binding protein 1
    • OBFC2A
    • Oligonucleotide/oligosaccharide binding fold containing 2A
    • Oligonucleotide/oligosaccharide binding fold containing protein 2A
    • Oligonucleotide/oligosaccharide-binding fold-containing protein 2A
    • Sensor of single strand DNA complex subunit B2
    • Sensor of single-strand DNA complex subunit B2
    • Sensor of ssDNA subunit B2
    • Single stranded DNA binding protein 2
    • Single-stranded DNA-binding protein 2
    • SOSB2_HUMAN
    • SOSS B2
    • SOSS complex subunit B2
    • SOSS-B2
    • SSB2
    see all
  • Function

    Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
  • Sequence similarities

    Belongs to the SOSS-B family. SOSS-B2 subfamily.
    Contains 1 OB DNA-binding domain.
  • Cellular localization

    Nucleus. Localizes to nuclear foci following DNA damage.
  • Information by UniProt

References

ab127660 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab127660.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up