Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
      Q13516
    • Species
      Human
    • Sequence
      MASMTGGQQMGRGHHHHHHGNLYFQGGEFDSDASLVSSRPSSPEPDDLFL PARSKGSSGSAFTG GTVSSSTPSDCPPELSAELRGAMGSAGAHPGDKL GGSGFKSSSSSTSSSTSSAAASSTKKDKKQ MTEPELQQLRLKINSRER KRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTN SL EEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPA VHHPILPPAAAA AAAAAAAAAVSSASLPGSGLPSVGSIRPPHGLLKSP SAAAAAPLGGGGGGSGASGGFQHWGGMP CPCSMCQVPPPHHHVSAMGA GSLPRLTSDAK
    • Molecular weight
      35 kDa
    • Amino acids
      1 to 323
    • Tags
      His-T7 tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab169905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    >90% by SDS-PAGE.
    ab169905 was expressed in E.coli as inclusion bodies. The final product was refolded and chromatographically purified.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituent: 0.32% Tris HCl
    Note: Contains NaCl, KCl, EDTA, arginine, DTT and glycerol.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Basic domain helix loop helix protein class B 1
    • Basic helix loop helix protein class B 1
    • BHLHB
    • bHLHB1
    • bHLHe19
    • Class B basic helix loop helix protein 1
    • Class B basic helix-loop-helix protein 1
    • class E basic helix loop helix protein 19
    • Class E basic helix-loop-helix protein 19
    • Human protein kinase C binding protein RACK17
    • Olig2
    • OLIG2_HUMAN
    • Oligo2
    • Oligodendrocyte lineage transcription factor 2
    • Oligodendrocyte specific bHLH transcription factor 2
    • Oligodendrocyte transcription factor 2
    • OTTHUMP00000067569
    • OTTHUMP00000067570
    • PRKCBP2
    • Protein kinase C binding protein 2
    • Protein kinase C binding protein RACK17
    • Protein kinase C-binding protein 2
    • Protein kinase C-binding protein RACK17
    • RACK17
    see all
  • Function
    Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
  • Tissue specificity
    Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
  • Involvement in disease
    Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
  • Sequence similarities
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • Domain
    The bHLH is essential for interaction with NKX2-2.
  • Cellular localization
    Nucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
  • Information by UniProt

References

ab169905 has not yet been referenced specifically in any publications.

Publishing research using ab169905? Please let us know so that we can cite the reference in this datasheet.

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