Recombinant human Olig2 protein (ab169905)
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Overview
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Product nameRecombinant human Olig2 protein
See all Olig2 proteins and peptides -
Protein lengthFull length protein
Description
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NatureRecombinant
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SourceEscherichia coli
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Amino Acid Sequence
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Accession
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SpeciesHuman
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SequenceMASMTGGQQMGRGHHHHHHGNLYFQGGEFDSDASLVSSRPSSPEPDDLFL PARSKGSSGSAFTG GTVSSSTPSDCPPELSAELRGAMGSAGAHPGDKL GGSGFKSSSSSTSSSTSSAAASSTKKDKKQ MTEPELQQLRLKINSRER KRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTN SL EEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPA VHHPILPPAAAA AAAAAAAAAVSSASLPGSGLPSVGSIRPPHGLLKSP SAAAAAPLGGGGGGSGASGGFQHWGGMP CPCSMCQVPPPHHHVSAMGA GSLPRLTSDAK
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Molecular weight35 kDa
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Amino acids1 to 323
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TagsHis-T7 tag N-Terminus
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab169905 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Purity>90% by SDS-PAGE.
ab169905 was expressed in E.coli as inclusion bodies. The final product was refolded and chromatographically purified. -
FormLiquid
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituent: 0.32% Tris HCl
Note: Contains NaCl, KCl, EDTA, arginine, DTT and glycerol.This product is an active protein and may elicit a biological response in vivo, handle with caution.
General Info
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Alternative names
- Basic domain helix loop helix protein class B 1
- Basic helix loop helix protein class B 1
- BHLHB
see all -
FunctionRequired for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
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Tissue specificityExpressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
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Involvement in diseaseNote=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
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Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
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DomainThe bHLH is essential for interaction with NKX2-2.
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Cellular localizationNucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
- Information by UniProt
Datasheets and documents
References
ab169905 has not yet been referenced specifically in any publications.