Recombinant human Olig2 protein (ab169905)

Product name

Recombinant human Olig2 protein
See all Olig2 proteins and peptides
Protein length

Full length protein

Nature

Recombinant
Source

Escherichia coli
Amino Acid Sequence
- Accession
  
  Q13516
- Species
  
  Human
- Sequence
  
  MASMTGGQQMGRGHHHHHHGNLYFQGGEFDSDASLVSSRPSSPEPDDLFL PARSKGSSGSAFTG GTVSSSTPSDCPPELSAELRGAMGSAGAHPGDKL GGSGFKSSSSSTSSSTSSAAASSTKKDKKQ MTEPELQQLRLKINSRER KRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTN SL EEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPA VHHPILPPAAAA AAAAAAAAAVSSASLPGSGLPSVGSIRPPHGLLKSP SAAAAAPLGGGGGGSGASGGFQHWGGMP CPCSMCQVPPPHHHVSAMGA GSLPRLTSDAK
- Molecular weight
  
  35 kDa
- Amino acids
  
  1 to 323
- Tags
  
  His-T7 tag N-Terminus

Related Products

Our Abpromise guarantee covers the use of ab169905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications

SDS-PAGE
Purity

>90% by SDS-PAGE.
ab169905 was expressed in E.coli as inclusion bodies. The final product was refolded and chromatographically purified.
Form

Liquid
Concentration information loading...

Stability and Storage

Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

pH: 8.00
Constituent: 0.32% Tris HCl
Note: Contains NaCl, KCl, EDTA, arginine, DTT and glycerol.

This product is an active protein and may elicit a biological response in vivo, handle with caution.

Alternative names
- Basic domain helix loop helix protein class B 1
- Basic helix loop helix protein class B 1
- BHLHB
- bHLHB1
- bHLHe19
- Class B basic helix loop helix protein 1
- Class B basic helix-loop-helix protein 1
- class E basic helix loop helix protein 19
- Class E basic helix-loop-helix protein 19
- Human protein kinase C binding protein RACK17
- Olig2
- OLIG2_HUMAN
- Oligo2
- Oligodendrocyte lineage transcription factor 2
- Oligodendrocyte specific bHLH transcription factor 2
- Oligodendrocyte transcription factor 2
- OTTHUMP00000067569
- OTTHUMP00000067570
- PRKCBP2
- Protein kinase C binding protein 2
- Protein kinase C binding protein RACK17
- Protein kinase C-binding protein 2
- Protein kinase C-binding protein RACK17
- RACK17
see all
Function

Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
Tissue specificity

Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
Involvement in disease

Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain.
Domain

The bHLH is essential for interaction with NKX2-2.
Cellular localization

Nucleus. Cytoplasm. The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
Target information above from: UniProt accession Q13516 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

Datasheet

ab169905 has not yet been referenced specifically in any publications.

Publishing research using ab169905? Please let us know so that we can cite the reference in this datasheet.

Location selector

Your location is currently set to:

Partner with us

Recombinant human Olig2 protein (ab169905)

Overview

Description

Associated products

Specifications

Preparation and Storage

General Info

Datasheets and documents

References

Customer reviews and Q&As