The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Candidate tumor suppressor in ovarian cancer 1
Diphthamide biosynthesis protein 1
Diphthamide biosynthesis protein 2 homolog like 1
Diphthamide biosynthesis protein 2 homolog-like 1
Diphthamide biosynthesis protein 2 like
Diphthamide biosynthesis protein 2-like
Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces) like 1
Diptheria toxin resistance protein required for diphthamide biosynthesis like 1
DPH like 1
DPH like 1 (S. cerevisiae)
DPH1 homolog (S. cerevisiae)
DPH2 like 1
Ovarian cancer associated gene 1
Ovarian cancer associated gene 1 protein
Ovarian cancer-associated gene 1 protein
Ovarian tumor suppressor candidate 1
Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival.
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors.