Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHHSSGLVPRGSHMAEPWGNELASAAARGDLEQLTSLLQNNVN VNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARA GFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV GHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
    • Molecular weight

      21 kDa including tags
    • Amino acids

      1 to 168
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab119460 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Purity

    > 95 % SDS-PAGE.
    ab119460 was purified using conventional chromatography techniques.
  • Form

    Liquid
  • Additional notes

     This product was previously labelled as p18 INK4c

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.03% DTT, 10% Glycerol, 1.17% Sodium chloride

General Info

  • Alternative names

    • CDK6 inhibitor p18
    • CDKN 2C
    • CDKN 6
    • Cdkn2c
    • CDKN6
    • CDN2C_HUMAN
    • Cyclin dependent inhibitor
    • Cyclin dependent kinase 4 inhibitor C
    • Cyclin dependent kinase 6 inhibitor
    • Cyclin dependent kinase 6 inhibitor p18
    • Cyclin dependent kinase inhibitor 2C
    • Cyclin dependent kinase inhibitor 2C (p18 inhibits CDK4)
    • Cyclin-dependent kinase 4 inhibitor C
    • Cyclin-dependent kinase 6 inhibitor
    • INK4C
    • OTTHUMP00000046546
    • p18
    • p18 inhibits CDK4
    • p18 INK4c
    • p18 INK6
    • p18-INK4c
    • p18-INK6
    see all
  • Function

    Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
  • Tissue specificity

    Highest levels found in skeletal muscle. Also found in pancreas and heart.
  • Sequence similarities

    Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
    Contains 4 ANK repeats.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab119460 at approximately 20.7kDa (3µg).

References

ab119460 has not yet been referenced specifically in any publications.

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