Overview

  • Product name

    Recombinant Human PACS2 protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      MAERGRLGLPGAPGALNTPVPMNLFATWEVDGSSPSCVPRLCSLTLKKLV VFKELEKELISVVIAVKMQGSKRILRSHEIVLPPSGQVETDLALTFSLQY PHFLKREGNKLQIMLQRRKRYKNRTILGYKTLAAGSISMAEVMQHPSEGG QVLSLCSSIKEAPVKAADIWIASLSSQPIDHEDSTMQAGPKAKSTDNYSE EEYESFSSEQEASDDAVQGQDLDEDDFDVGKPKKQRRSIVRTTSMTRQQN FKQKVVALLRRFKVSGEVLDSEQDPAEHIPEAEEDLDLLYDTLDMEHPSD SGPDMEDDDSVLSTPKPKLRPYFEGLSHSSSQTEIGSIHSARSHKEPPSP ADVPEKTRSLGGRQPSDSVSDTVALGVPGPREHPGQPEDSPEAEASTLDV FTERLPPSGRITKTESLVIPSTRSEGKQAGRRGRSTSLKERQAARPQNER ANSLDNERCPDARSQLQIHRKTVYDQLNDILISDDQLPENIILVNTSDWQ GQFLSDVLQRHTLPVVCTCSPADVQAAFSTIVSRIQRYCNCNSQPPTPVK IAVAGAQHYLSAILRLFVEQLSHKTPDWLGYMRFLVIPLGSHPVARYLGS VDYRYNNFFQDLAWRDLFNKLEAQSAVQDTPDIVSRITQYIAGANCAHQL PIAEAMLTYKQKSPDEESSQKFIPFVGVVKVGIVEPSSATSGDSDDAAPS GSGTLSSTPPSASPAAKEASPTPPSSPSVSGGLSSPSQGVGAELMGLQVD YWTAAQPADRKRDAEKKDLPVTKNTLKCTFRSLQVSRLPSSGEAAATPTM SMTVVTKEKNKKVMFLPKKAKDKDVESKSQCIEGISRLICTARQQQNMLR VLIDGVECSDVKFFQLAAQWSSHVKHFPICIFGHSKATF
    • Amino acids

      1 to 889
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab161579 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • 6720425G15Rik
    • AW208651
    • AW489976
    • E230011J22
    • FLJ25488
    • KIAA0602
    • mKIAA0602
    • PACS 2
    • PACS-2
    • PACS1 like protein
    • PACS1-like protein
    • PACS1L
    • PACS2
    • PACS2_HUMAN
    • Phosphofurin acidic cluster sorting protein 1 like
    • Phosphofurin acidic cluster sorting protein 2
    see all
  • Function

    Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
  • Tissue specificity

    Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis.
  • Sequence similarities

    Belongs to the PACS family.
  • Cellular localization

    Endoplasmic reticulum lumen. Mitochondrion.
  • Information by UniProt

Images

  • ab161579 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab161579 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab161579.
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