Description

  • Product name

    Recombinant Human PAPP A protein
    See all PAPP A proteins and peptides
  • Purity

    > 95 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      REARGATEEP SPPSRALYFS GRGEQLRLRA DLELPRDAFT LQVWLRAEGG QRSPAVITGL YDKCSYISRD RGWVVGIHTI SDQDNKDPRY FFSLKTDRAR QVTTINAHRS YLPGQWVYLA ATYDGQFMKL YVNGAQVATS GEQVGGIFSP LTQKCKVLML GGSALNHNYR GYIEHFSLWK VARTQREILS
    • Amino acids

      81 to 271

Specifications

Our Abpromise guarantee covers the use of ab53389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.242% Tris, 50% Glycerol

General Info

  • Alternative names

    • ASBABP2
    • Aspecific BCL2 ARE binding protein 2
    • Differentially placenta 1 expressed protein
    • DIPLA1
    • EC 3.4.24.79
    • IGF dependent IGFBP 4 protease
    • IGF-dependent IGFBP-4 protease
    • IGFBP 4ase
    • IGFBP-4ase
    • IGFBP4ase
    • Insulin like growth factor dependent IGF binding protein 4 protease
    • Insulin-like growth factor-dependent IGF-binding protein 4 protease
    • PAPA
    • PAPP A
    • PAPP-A
    • PAPP1_HUMAN
    • PAPPA
    • PAPPA1
    • Pappalysin 1 precursor
    • Pappalysin-1
    • Pregnancy Associated Plasma Protein A
    • Pregnancy associated plasma protein A pappalysin 1
    • Pregnancy-associated plasma protein A
    see all
  • Function

    Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
  • Tissue specificity

    High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.
  • Sequence similarities

    Belongs to the peptidase M43B family.
    Contains 5 Sushi (CCP/SCR) domains.
  • Developmental stage

    Present in serum and placenta during pregnancy; levels increase throughout pregnancy.
  • Post-translational
    modifications

    There appear to be no free sulfhydryl groups.
  • Cellular localization

    Secreted.
  • Information by UniProt

Images

  • SDS PAGE analysis of ab53389.

References

ab53389 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Question
Answer

Thank you for your enquiry. The concentration of the protein is 0.1mg/ml. The buffer is PBS/50% glycerol. To our knowledge, the activity has not been determined. I hope this information helps. Please do not hesitate to contact us if you need any more advice or information.

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