The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Par 6 partitioning defective 6 C elegans homolog alpha
Par 6 partitioning defective 6 homolog alpha
Par 6 partitioning defective 6 homolog alpha C elegans
par-6 family cell polarity regulator alpha
Partitioning defective 6 homolog alpha
partitioning-defective protein 6
partitioning-defective protein 6, C. elegans, homolog of, alpha
Tax interacting protein 40
Tax interaction protein 40
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
Belongs to the PAR6 family. Contains 1 OPR domain. Contains 1 PDZ (DHR) domain. Contains 1 pseudo-CRIB domain.
The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases. The OPR domain mediates interactions with MAP2K5. The PDZ domain mediates the interaction with CRB3.
Cytoplasm. Cell membrane. Cell projection > ruffle. Cell junction > tight junction. Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.