Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
Expressed in most tissues. Most abundant in kidney, bone and liver.
Involvement in disease
Jansen metaphyseal chondrodysplasia Chondrodysplasia Blomstrand type Enchondromatosis multiple Eiken skeletal dysplasia Primary failure of tooth eruption
Belongs to the G-protein coupled receptor 2 family.