Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMQLDLR VQELIKLICN VQAMEEMMME MKYNTKKAPL GKLTVAQIKA GYQSLKKIED CIRAGQHGRA LMEACNEFYT RIPHDFGLRT PPLIRTQKEL SEKIQLLEAL GDIEIAIKLV KTELQSPEHP LDQHYRNLHC ALRPLDHESY EFKVISQYLQ STHAPTHSDY TMTLLDLFEV EKDGEKEAFR EDLHNRMLLW HGSRMSNWVG ILSHGLRIAP PEAPITGYMF GKGIYFADMS SKSANYCFAS RLKNTGLLLL SEVALGQCNE LLEANPKAEG LLQGKHSTKG LGKMAPSSAH FVTLNGSTVP LGPASDTGIL NPDGYTLNYN EYIVYNPNQV RMRYLLKVQF NFLQLW
    • Molecular weight

      43 kDa including tags
    • Amino acids

      233 to 583
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab140564 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 85 % SDS-PAGE.

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • ADP ribosyltransferase like 2
    • ADP-ribosyltransferase diphtheria toxin-like 2
    • ADPRT 2
    • ADPRT-2
    • ADPRT2
    • ADPRTL 2
    • ADPRTL 3
    • ADPRTL2
    • ADPRTL3
    • ARTD2
    • hPARP 2
    • hPARP-2
    • hPARP2
    • NAD(+) ADP ribosyltransferase 2
    • NAD(+) ADP-ribosyltransferase 2
    • pADPRT 2
    • pADPRT-2
    • pADPRT2
    • PARP 2
    • PARP-2
    • PARP2
    • PARP2_HUMAN
    • Poly (ADP ribose) polymerase family member 2
    • Poly (ADP ribosyl) transferase like 2
    • poly (ADP-ribose) polymerase 2
    • Poly [ADP ribose] synthetase 2
    • Poly [ADP-ribose] polymerase 2
    • Poly(ADP ribose) synthetase
    • Poly[ADP-ribose] synthase 2
    see all
  • Function

    Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
  • Tissue specificity

    Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus.
  • Sequence similarities

    Contains 1 PARP alpha-helical domain.
    Contains 1 PARP catalytic domain.
  • Post-translational
    modifications

    Poly-ADP-ribosylated by PARP1.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • 15% SDS PAGE analysis of ab140564 (3 µg).

References

ab140564 has not yet been referenced specifically in any publications.

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