Recombinant human PARP9 protein (ab79665)

Overview

  • Product name
    Recombinant human PARP9 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Species
      Human

Associated products

Specifications

Our Abpromise guarantee covers the use of ab79665 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific Activity: 196 U/mg.
  • Applications

    SDS-PAGE

    Functional Studies

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.0462% DTT, 0.395% Tris HCl, 0.05% Tween, 50% Glycerol, 0.58% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • ADP-ribosyltransferase diphtheria toxin-like 9
    • ARTD9
    • AW214463
    • B aggressive lymphoma protein
    • Bagl
    • BAL
    • BAL1
    • BC003281
    • DKFZp666B0810
    • DKFZp686M15238
    • EC 2.4.2.30
    • FLJ26637
    • FLJ35310
    • FLJ41418
    • FLJ43593
    • MGC:7868
    • MGC156739
    • MGC7868
    • OTTMUSP00000028034
    • PARP 9
    • PARP-9
    • Parp9
    • PARP9_HUMAN
    • Poly (ADP ribose) polymerase family member 9
    • Poly [ADP-ribose] polymerase 9
    • RGD1307534
    see all
  • Function
    Involved in inducing the expression of IFN-gamma-responsive genes.
  • Tissue specificity
    Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form. Most abundantly expressed in lymphomas with a brisk host inflammatory response. In diffuse large B-cell lymphomas tumors, expressed specifically by malignant B-cells.
  • Involvement in disease
    Note=Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors.
  • Sequence similarities
    Contains 2 Macro domains.
    Contains 1 PARP catalytic domain.
  • Cellular localization
    Cytoplasm > cytosol. Nucleus. Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L.
  • Information by UniProt

Images

  • SDS-PAGE showing ab79665 at approximately 119kDa (4µg).

References

ab79665 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for contacting us.

The lab let me know that the protein is a (proprietary tag)-PARP9-His. It has the proprietary tag on the N-terminus and a C-terminal 6x His-tag.

I hope this helps explain your results.

Please...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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