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    recombinant-human-pax7-protein-ab114237.pdf

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Epigenetics and Nuclear Signaling Transcription Domain Families Developmental Families PAX
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Recombinant Human PAX7 protein (ab114237)

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SDS-PAGE - Recombinant Human PAX7 protein (ab114237)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: ELISA, SDS-PAGE, WB

    Description

    • Product name

      Recombinant Human PAX7 protein
    • Expression system

      Wheat germ
    • Accession

      P23759
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        GGLDSATSISASCSQRADSIKPGDSLPTSQAYCPPTYSTTGYSVDPVAGY QYGQYGQSECLVPWASPVPIPSPTPRASCLFMESYKVVSGWGMSISQMEK LKSSQMEQFT
      • Predicted molecular weight

        38 kDa including tags
      • Amino acids

        411 to 521

    Associated products

    • Related Products

      • Anti-PAX7 antibody (ab34360)

    Specifications

    Our Abpromise guarantee covers the use of ab114237 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      SDS-PAGE

      Western blot

    • Form

      Liquid
    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.3% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • FLJ37460
      • HUP1
      • OTTHUMP00000002534
      • Paired box 7
      • Paired box gene 7
      • Paired box homeotic gene 7
      • Paired box protein Pax-7
      • Paired domain gene 7
      • Paired domain gene HuP1
      • Pax7
      • PAX7 transcriptional factor
      • PAX7/FKHR fusion gene, included
      • PAX7_HUMAN
      • PAX7B
      • RGD1564360
      • RMS2
      see all
    • Function

      Probable transcription factor. May have a role in myogenesis.
    • Involvement in disease

      Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2) [MIM:268220]. It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator.
    • Sequence similarities

      Belongs to the paired homeobox family.
      Contains 1 homeobox DNA-binding domain.
      Contains 1 paired domain.
    • Cellular localization

      Nucleus.
    • Target information above from: UniProt accession P23759 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human PAX7 protein (ab114237)
      SDS-PAGE - Recombinant Human PAX7 protein (ab114237)
      12.5% SDS-PAGE showing ab114237 at approximately 38.21kDa stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab114237? Please let us know so that we can cite the reference in this datasheet.

    ab114237 has not yet been referenced specifically in any publications.

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