The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Heterogeneous nuclear ribonucleoprotein E2
Heterogenous nuclear ribonucleoprotein E2
poly(rC) binding protein 2
Poly(rC)-binding protein 2
Putative heterogeneous nuclear ribonucleoprotein X
rCbinding protein 2
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation.
Detected in all tissues examined.
Contains 3 KH domains.
Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity.
Nucleus. Cytoplasm. Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.