It is recommended to reconstitute the lyophilized protein in 20µl sterile deionized water to a final concentration of 1mg/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage.
Convertase subtilisin/kexin type 9 preproprotein
Hypercholesterolemia autosomal dominant 3
Neural apoptosis regulated convertase 1
Neural apoptosis-regulated convertase 1
Proprotein convertase 9
Proprotein convertase PC9
Proprotein convertase subtilisin/kexin type 9
Subtilisin/kexin like protease PC9
Subtilisin/kexin-like protease PC9
May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
Involvement in disease
Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
Belongs to the peptidase S8 family. Contains 1 peptidase S8 domain.
The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.