Description

  • Product name

    Recombinant Human PD1 protein
    See all PD1 proteins and peptides
  • Purity

    > 90 % SDS-PAGE.
    >90% purity as measured by gel filtration.
  • Expression system

    HEK 293 cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      LDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSN QTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCG AISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQ
    • Predicted molecular weight

      20 kDa including tags
    • Amino acids

      25 to 167
    • Additional sequence information

      C-terminal FLAG-Avi-His-tags (NM_005018).

Specifications

Our Abpromise guarantee covers the use of ab233685 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituents: 0.64% Sodium chloride, 0.02% Potassium chloride, 20% Glycerol, Phosphate Buffer

General Info

  • Alternative names

    • CD279
    • CD279 antigen
    • hPD 1
    • hPD l
    • hPD-1
    • hSLE1
    • PD 1
    • PD-1
    • PD1
    • PDCD 1
    • PDCD1
    • PDCD1_HUMAN
    • Programmed cell death 1
    • Programmed cell death 1 protein
    • Programmed cell death protein 1
    • Protein PD 1
    • Protein PD-1
    • SLEB2
    • Systemic lupus erythematosus susceptibility 2
    see all
  • Function

    Possible cell death inducer, in association with other factors.
  • Involvement in disease

    Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
  • Sequence similarities

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Developmental stage

    Induced at programmed cell death.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • 4-20%% SDS-PAGE analysis of 3 µg ab233685, stained with Coomassie.

    This protein runs at a higher M.W. by SDS-PAGE due to glycosylation.

  • Gel Filtration curve.

  • 10 nM PD-L1 was Biotin labeled then mixed with varying amounts of PD-1, FLAG-tag in PD-1 Assay Buffer for 1 hr at RT. FLAG-acceptor beads were added and incubated for 30 min at RT followed by streptavidin-conjugated donor beads for 30 min at RT. Alpha counts were read.

  • 10 nM PD-L1, was Biotin labeled then mixed with varying amounts of PD-1, FLAG-tag in PD-1 Assay Buffer for 1 hr at RT. Nickel-acceptor beads were added and incubated for 30 min at RT followed by streptavidin-conjugated donor beads for 30 min at RT. Alpha counts were read.

References

ab233685 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab233685.
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