Recombinant human PD1 protein (Fc Chimera Active) (ab215017)

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Key features and details

  • Expression system: CHO cells
  • Purity: >= 98% SDS-PAGE
  • Endotoxin level: < 0.060 Eu/µg
  • Active: Yes
  • Suitable for: Functional Studies, SDS-PAGE

Description

  • Product name

    Recombinant human PD1 protein (Fc Chimera Active)
    See all PD1 proteins and peptides

  • Biological activity

    Shows the biological function of the PD1 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.

  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

    < 0.060 Eu/µg

  • Expression system

    CHO cells

  • Accession

    Q15116

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      LDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSN QTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCG AISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQ

    • Predicted molecular weight

      16 kDa

    • Amino acids

      25 to 167

    • Additional sequence information

      Fused to the N-terminus of the Fc region of a mutant human IgG1 (NP_005009.2).

Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab215017 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Functional Studies

      SDS-PAGE

    • Form

      Lyophilized

    • Additional notes

      Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

      Constituent: 100% PBS

      Lyophilised from 0.2µm filtered solution.

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • Reconstitution
      Reconstitute at 100 µg/mL in sterile PBS.

    General Info

    • Alternative names

      • CD279
      • CD279 antigen
      • hPD 1
      • hPD l
      • hPD-1
      • hSLE1
      • PD 1
      • PD-1
      • PD1
      • PDCD 1
      • PDCD1
      • PDCD1_HUMAN
      • Programmed cell death 1
      • Programmed cell death 1 protein
      • Programmed cell death protein 1
      • Protein PD 1
      • Protein PD-1
      • SLEB2
      • Systemic lupus erythematosus susceptibility 2
      see all

    • Function

      Possible cell death inducer, in association with other factors.

    • Involvement in disease

      Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

    • Sequence similarities

      Contains 1 Ig-like V-type (immunoglobulin-like) domain.

    • Developmental stage

      Induced at programmed cell death.

    • Cellular localization

      Membrane.
    • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab215017? Please let us know so that we can cite the reference in this datasheet.

    ab215017 has not yet been referenced specifically in any publications.

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