Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
      P54750-4
    • Species
      Human
    • Molecular weight
      64 kDa including tags
    • Amino acids
      2 to 545
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab125661 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    The specific activity of ab125661 was determined to be 12250 - 12290 nmol/min/mg.
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity
    > 90 % Densitometry.
    Purity was determined to be >90% by densitometry.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 1.05% MOPS, 0.002% PMSF, 0.004% DTT, 25% Glycerol, 1.75% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 3' 5' cyclic nucleotide phosphodiesterase
    • 5''-cyclic nucleotide phosphodiesterase 1A
    • 61 kDa Cam PDE
    • 61 kDa Cam-PDE
    • Calcium/calmodulin dependent 3' 5' cyclic nucleotide phosphodiesterase 1A
    • Calcium/Calmodulin stimulated cyclic nucleotide phosphodiesterase
    • Calcium/calmodulin-dependent 3''
    • Calmodulin-dependent Phosphodiesterase
    • Cam PDE 1A
    • Cam-PDE 1A
    • CAM-PDE-1A
    • HCAM 1
    • hCam-1
    • HCAM1
    • HSPDE1A
    • MGC26303
    • PDE 1A
    • PDE1A
    • PDE1A_HUMAN
    • Phosphodiesterase 1A
    • Phosphodiesterase 1A calmodulin dependent
    see all
  • Function
    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
  • Tissue specificity
    Several tissues, including brain, kidney, testes and heart.
  • Sequence similarities
    Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant human PDE1A protein (ab125661)
    SDS-PAGE - Recombinant human PDE1A protein (ab125661)
    SDS-PAGE analysis of ab125661.
  • Functional Studies - Recombinant human PDE1A protein (ab125661)
    Functional Studies - Recombinant human PDE1A protein (ab125661)
    Sample Phosphodiesterase Assay showing the specific activity of ab125661 as 12250 nmol/min/mg.

References

ab125661 has not yet been referenced specifically in any publications.

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