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Signal Transduction Second Messenger Nucleotide Messenger cAMP
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Recombinant human PDE2A protein (ab125613)

  • Datasheet
  • SDS
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Functional Studies - Recombinant human PDE2A protein (ab125613)
  • SDS-PAGE - Recombinant human PDE2A protein (ab125613)
  • Functional Studies - Recombinant human PDE2A protein (ab125613)
  • SDS-PAGE - Recombinant human PDE2A protein (ab125613)

Key features and details

  • Expression system: Baculovirus infected Sf9 cells
  • Purity: > 70% SDS-PAGE
  • Active: Yes
  • Suitable for: Functional Studies, SDS-PAGE

Description

  • Product name

    Recombinant human PDE2A protein
    See all PDE2A proteins and peptides
  • Biological activity

    The specific activity of ab125613 was determined to be 6000 nmol/mg/min.
  • Purity

    > 70 % SDS-PAGE.
    Purity determined to be >70% by densitometry.
  • Expression system

    Baculovirus infected Sf9 cells
  • Accession

    O00408
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      130 kDa including tags
    • Amino acids

      2 to 941

Specifications

Our Abpromise guarantee covers the use of ab125613 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • 5''-cyclic phosphodiesterase
    • cGMP dependent 3'5' cyclic phosphodiesterase
    • cGMP stimulated phosphodiesterase 1
    • cGMP stimulated phosphodiesterase 4
    • cGMP-dependent 3''
    • cGMP-stimulated phosphodiesterase 2
    • CGS PDE
    • CGS-PDE
    • cGSPDE
    • Cyclic GMP stimulated phosphodiesterase
    • Cyclic GMP-stimulated phosphodiesterase
    • Human cGMP stimulated 3'5' cyclic nucleotide phosphodiesterase
    • PDE 2A
    • PDE 2A1
    • PDE 2A4
    • PDE2A
    • PDE2A_HUMAN
    • PDE2A1
    • PDE2A4
    • phosphodiesterase 2A
    • Phosphodiesterase 2A cGMP stimulated
    see all
  • Function

    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
  • Tissue specificity

    Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.
  • Sequence similarities

    Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.
    Contains 2 GAF domains.
  • Domain

    GAF 1 functions as a dimerization domain, whereas GAF 2 binds cGMP, which causes activation of the catalytic activity of the enzyme.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession O00408 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Images

  • Functional Studies - Recombinant human PDE2A protein (ab125613)
    Functional Studies - Recombinant human PDE2A protein (ab125613)
    The specific activity of PDE2A (ab125613) was determined to be ~6000 nmol/min/mg as per activity assay protocol
  • SDS-PAGE - Recombinant human PDE2A protein (ab125613)
    SDS-PAGE - Recombinant human PDE2A protein (ab125613)
    SDS PAGE analysis of ab125613
  • Functional Studies - Recombinant human PDE2A protein (ab125613)
    Functional Studies - Recombinant human PDE2A protein (ab125613)
    Sample Phosphodiesterase Assay showing the specific activity of ab125613 as 5750 nmol/mg/min.
  • SDS-PAGE - Recombinant human PDE2A protein (ab125613)
    SDS-PAGE - Recombinant human PDE2A protein (ab125613)
    SDS-PAGE analysis of ab125613.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab125613? Please let us know so that we can cite the reference in this datasheet.

ab125613 has not yet been referenced specifically in any publications.

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