Recombinant human PDE4B protein (ab56612)

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Key features and details

  • Expression system: Baculovirus infected Sf9 cells
  • Active: Yes
  • Tags: GST tag N-Terminus
  • Suitable for: SDS-PAGE, Functional Studies

Description

  • Product name

    Recombinant human PDE4B protein
    See all PDE4B proteins and peptides

  • Biological activity

    Specific Activity: 10000 U/µg.

  • Expression system

    Baculovirus infected Sf9 cells

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Tags

      GST tag N-Terminus

Associated products

Specifications

Our Abpromise guarantee covers the use of ab56612 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.1535% Glutathione, 0.0462% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.395% Tris HCl, 0.05% Tween, 50% Glycerol (glycerin, glycerine), 0.58% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • 5''-cyclic phosphodiesterase 4B
    • cAMP-specific 3''
    • cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    • cAMP-specific phosphodiesterase-4 B isoform
    • DKFZp686F2182
    • DPDE4
    • dunce-like phosphodiesterase E4
    • MGC126529
    • OTTHUMP00000010652
    • OTTHUMP00000010653
    • OTTHUMP00000010654
    • OTTHUMP00000010656
    • OTTHUMP00000232365
    • PDE 4B
    • PDE IVB
    • PDE32
    • Pde4b
    • PDE4B_HUMAN
    • PDE4B5
    • PDEIVB
    • Phosphodiesterase 4B
    • Phosphodiesterase 4B cAMP specific
    • Phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila)
    see all

  • Function

    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

  • Tissue specificity

    Expressed in brain, heart, lung and skeletal muscle.

  • Pathway

    Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

  • Sequence similarities

    Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
  • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab56612? Please let us know so that we can cite the reference in this datasheet.

ab56612 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Question

Bonjour,
Je souhaiterais vous commander la PDE4B protein (Tagged), ref: ab56612, mais j'ai besoin d'une information complémentaire :
Quelle est l'isoforme de cette PDE4B? La reference Uniprot donnée dans la fiche technique (Q07343) peut correspondre à l'une des trois isoformes PDE4B1 (Q07343-1), PDE4B2 (Q07343-2) ou PDE4B3 (Q07343-3)...
De plus, je souhaiterais commander 10ug, pourriez-vous me redonner le prix s'il vous plait?
Je vous remercie par avance.
Cordialement,

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Answer

Merci de nous avoir contactés.

La protéinehttps://www.abcam.com/ab56612est l'isoformePDE4B1 (83.3 kDa) taguée à son extrémitéN-terminale. Le poids moléculaire total est de 109 kDa.

J'espère que ces informationsvousseront utiles. N'hésitez pas à nous contacter de nouveau si vous avez d'autres questions.

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