Description

  • Product name

    Recombinant Human PDE6H protein
  • Purity

    > 80 % SDS-PAGE.
    ab183245 was purified using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMSDNTTL PAPASNQGPT TPRKGPPKFK QRQTRQFKSK PPKKGVKGFG DDIPGMEGLG TDITVICPWE AFSHLELHEL AQFGII
    • Predicted molecular weight

      12 kDa including tags
    • Amino acids

      1 to 83
    • Tags

      His tag N-Terminus
    • Additional sequence information

      NP_006196.

Specifications

Our Abpromise guarantee covers the use of ab183245 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.0
    Constituents: 0.32% Tris HCl, 1.17% Sodium chloride, 40% Glycerol, 0.03% DTT, 0.002% PMSF

General Info

  • Alternative names

    • 5''-cyclic phosphodiesterase subunit gamma
    • CNCG_HUMAN
    • GMP-PDE gamma
    • Pde6h
    • Retinal cone rhodopsin-sensitive cGMP 3''
    see all
  • Function

    Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
  • Involvement in disease

    Defects in PDE6H are the cause of cone dystrophy retinal type 3A (RCD3A) [MIM:610024]; also known as cone dystrophy with night blindness and supernormal rod responses. RCD3A is a rare form of cone dystrophy associated with supernormal rod responses. The disorder is characterized by reduced visual acuity, photoaversion, night blindness, and abnormal color vision. At an early age, the retina shows subtle depigmentation at the macula and, later, more obvious areas of atrophy.
  • Sequence similarities

    Belongs to the rod/cone cGMP-PDE gamma subunit family.
  • Domain

    The C-terminal region is important in conferring inhibition.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab183245 (3μg).

References

ab183245 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab183245.
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