Recombinant human PDGF AA protein (Animal Free) (ab217387)

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Description

  • Product name

    Recombinant human PDGF AA protein (Animal Free)
    See all PDGF AA proteins and peptides

  • Biological activity

    The ED50 as determined by the dose-dependent stimulation of thymidine uptake by Balb/c 3T3 cells is ≤ 1 ng/mL, corresponding to a specific activity of ≥ 1 x 106 units/mg.

  • Purity

    > 98 % SDS-PAGE.
    assessed also by HPLC

  • Expression system

    Escherichia coli

  • Accession

    P04085

  • Protein length

    Full length protein

  • Animal free

    Yes

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPT

    • Predicted molecular weight

      29 kDa

    • Amino acids

      87 to 211

    • Additional sequence information

      Full length mature disulfide-linked homodimer of two A chains

Associated products

Specifications

Our Abpromise guarantee covers the use of ab217387 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

    HPLC

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    For lot specific reconstitution information please contact our Scientific Support Team.

General Info

  • Alternative names

    • PDGF A
    • PDGF A chain
    • PDGF subunit A
    • PDGF-1
    • PDGF1
    • PDGFA
    • PDGFA_HUMAN
    • Platelet derived growth factor alpha chain
    • Platelet derived growth factor alpha isoform 2 preproprotein
    • Platelet derived growth factor alpha polypeptide
    • Platelet-derived growth factor A chain
    • Platelet-derived growth factor alpha polypeptide
    • Platelet-derived growth factor subunit A
    see all

  • Function

    Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.

  • Sequence similarities

    Belongs to the PDGF/VEGF growth factor family.

  • Domain

    The long form contains a basic insert which acts as a cell retention signal.

  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab217387 has not yet been referenced specifically in any publications.

Publishing research using ab217387? Please let us know so that we can cite the reference in this datasheet.

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