Overview

  • Product name

    Recombinant Human PDZRN3 protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEG SCPARCRGRLSAKELNHVLPLKRLILKLDIKCAYATRGCGRVVKLQQLPE HLERCDFAPARCRHAGCGQVLLRRDVEAHMRDACDARPVGRCQEGCGLPL THGEQRAGGHCCARALRAHNGALQARLGALHKALKKEALRAGKREKSLVA QLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTL VLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQI HDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSE SQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPN DYIGDIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYIS EIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLI ARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHDE DGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDATASSNPL AGQRKLTCSQDTLGSGDLPFSNESFISADCTDADYLGIPVDECERFRELL ELKCQVKSATPYGLYYPSGPLDAGKSDPESVDKELELLNEELRSIELECL SIVRAHKMQQLKEQYRESWMLHNSGFRNYNTSIDVRRHELSDITELPEKS DKDSSSAYNTGESCRSTPLTLEISPDNSLRRAAEGISCPSSEGAVGTTEA YGPASKNLLSITEDPEVGTPTYSPSLKELDPNQPLESKERRASDGSRSPT PSQKLGSAYLPSYHHSPYKHAHIPAHAQHYQSYMQLIQQKSAVEYAQSQM SLVSMCKDLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKI REERSGMTTDDDAVSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRL DCLKEQQAADDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKS PDGTRVYNSFLSVTTV
    • Amino acids

      1 to 1066
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab161507 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • E3 ubiquitin-protein ligase PDZRN3
    • KIAA1095
    • Ligand of Numb protein X 3
    • likely ortholog of mouse semaF cytoplasmic domain associated protein 3
    • LNX3
    • PDZ domain containing ring finger 3
    • PDZ domain-containing RING finger protein 3
    • Pdzrn3
    • Protein SEMACAP3
    • PZRN3_HUMAN
    • SEMACAP3
    • Semaphorin cytoplasmic domain associated protein
    • Semaphorin cytoplasmic domain-associated protein 3
    • SEMCAP3
    see all
  • Function

    E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.
  • Tissue specificity

    Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors.
  • Pathway

    Protein modification; protein ubiquitination.
  • Sequence similarities

    Contains 2 PDZ (DHR) domains.
    Contains 1 RING-type zinc finger.
    Contains 1 TRAF-type zinc finger.
  • Domain

    The RING-type zinc finger domain is required for E3 ligase activity.
  • Post-translational
    modifications

    Auto-ubiquitinated.
  • Information by UniProt

Images

  • ab161507 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab161507 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab161507.
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