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    recombinant-human-peg10edr-protein-ab161530.pdf

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Epigenetics and Nuclear Signaling Transcription Domain Families Zinc Finger
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Recombinant Human PEG10/EDR protein (ab161530)

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SDS-PAGE - Recombinant Human PEG10/EDR protein (ab161530)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    Description

    • Product name

      Recombinant Human PEG10/EDR protein
    • Expression system

      Wheat germ
    • Protein length

      Full length protein
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MTERRRDELSEEINNLREKVMKQSEENNNLQSQVQKLTEENTTLREQVEP TPEDEDDDIELRGAAAAAAPPPPIEEECPEDLPEKFDGNPDMLAPFMAQC QIFMEKSTRDFSVDRVRVCFVTSMMTGRAARWASAKLERSHYLMHNYPAF MMEMKHVFEDPQRREVAKRKIRRLRQGMGSVIDYSNAFQMIAQDLDWNEP ALIDQYHEGLSDHIQEELSHLEVAKSLSALIGQCIHIERRLARAAAARKP RSPPRALVLPHIASHHQVDPTEPVGGARMRLTQEEKERRRKLNLCLYCGT GGHYADNCPAKASKSSPAGNSPAPL
      • Amino acids

        1 to 325
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab161530 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      Western blot

    • Form

      Liquid
    • Additional notes

      This product was previously labelled as PEG10.

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • AA407948
      • Edr
      • Embryonal carcinoma differentiation regulated
      • Embryonal carcinoma differentiation-regulated protein
      • HB 1
      • HB1
      • KIAA1051
      • Mammalian retrotransposon-derived protein 2
      • Mar2
      • Mart2
      • MEF3 like 1
      • MEF3-like protein 1
      • MEF3L
      • MEF3L1
      • MyEF 3
      • Myelin expression factor 3-like protein 1
      • Paternally expressed 10
      • Paternally expressed gene 10 ORF1
      • Paternally expressed gene 10 protein
      • Peg10
      • PEG10 protein
      • PEG10_HUMAN
      • Putative uncharacterized protein PEG10
      • Retrotransposon gag domain containing 3
      • Retrotransposon gag domain-containing protein 3
      • Retrotransposon-derived gag-like polyprotein
      • Retrotransposon-derived protein PEG10
      • RGAG3
      • Ty3/Gypsy-like protein
      see all
    • Function

      Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.
    • Tissue specificity

      Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the HepG2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC).
    • Sequence similarities

      Contains 1 CCHC-type zinc finger.
    • Developmental stage

      Expressed in placenta during the first trimester of gestation (at protein level). In placenta, down-regulated at early hypoxic phase, and highly activated at 11-12 week of gestation.
    • Post-translational
      modifications

      Isoform RF1/RF2 undergoes proteolytic cleavage.
    • Cellular localization

      Nucleus. Cytoplasm. Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the HepG2 cell line. Colocalized with ALK1.
    • Target information above from: UniProt accession Q86TG7 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human PEG10/EDR protein (ab161530)
      SDS-PAGE - Recombinant Human PEG10/EDR protein (ab161530)
      ab161530 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab161530? Please let us know so that we can cite the reference in this datasheet.

    ab161530 has not yet been referenced specifically in any publications.

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