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    recombinant-human-per2-protein-ab112382.pdf

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Recombinant Human PER2 protein (ab112382)

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SDS-PAGE - Recombinant Human PER2 protein (ab112382)

    Key features and details

    • Expression system: Wheat germ
    • Suitable for: ELISA, SDS-PAGE, WB

    Description

    • Product name

      Recombinant Human PER2 protein
    • Biological activity

      Useful for Antibody Production and Protein Array
    • Expression system

      Wheat germ
    • Accession

      O15055
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTG RDSQGSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSD
      • Predicted molecular weight

        37 kDa including tags
      • Amino acids

        1 to 100

    Specifications

    Our Abpromise guarantee covers the use of ab112382 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      SDS-PAGE

      Western blot

    • Form

      Liquid
    • Additional notes

      This product is useful for Antibody Production and Protein Array.

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

      Glutathione is reduced

    General Info

    • Alternative names

      • Circadian clock protein PERIOD 2
      • FASPS
      • FASPS1
      • hPER 2
      • hPER2
      • KIAA0347
      • OTTHUMP00000164476
      • PER 2
      • PER2
      • PER2_HUMAN
      • Period 2
      • Period 2 isoform 1
      • Period circadian clock 2
      • Period circadian protein 2
      • Period circadian protein homolog 2
      • Period homolog 2
      • Period homolog 2 (Drosophila)
      • Period, Drosophila, homolog of, 2
      • Period2
      see all
    • Function

      Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK
      NPAS2-BMAL1
      BMAL2-induced transactivation.
    • Tissue specificity

      Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low level in lung.
    • Involvement in disease

      Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
    • Sequence similarities

      Contains 1 PAC (PAS-associated C-terminal) domain.
      Contains 2 PAS (PER-ARNT-SIM) domains.
    • Post-translational
      modifications

      Phosphorylated by CSNK1E and CSNK1D. Phosphorylation results in PER2 protein degradation.
    • Cellular localization

      Nucleus. Cytoplasm. Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2.
    • Target information above from: UniProt accession O15055 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human PER2 protein (ab112382)
      SDS-PAGE - Recombinant Human PER2 protein (ab112382)
      ab112382 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab112382? Please let us know so that we can cite the reference in this datasheet.

    ab112382 has not yet been referenced specifically in any publications.

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