Product nameRecombinant human Peroxiredoxin 1/PAG protein
See all Peroxiredoxin 1/PAG proteins and peptides
Protein lengthFull length protein
Amino Acid Sequence
SequenceMGSSHHHHHH SSGLVPRGSH MSSGNAKIGH PAPNFKATAV MPDGQFKDIS LSDYKGKYVV FFFYPLDFTF VCPTEIIAFS DRAEEFKKLN CQVIGASVDS HFCHLAWVNT PKKQGGLGPM NIPLVSDPKR TIAQDYGVLK ADEGISFRGL FIIDDKGILR QITVNDLPVG RSVDETLRLV QAFQFTDKHG EVCPAGWKPG SDTIKPDVQK SKEYFSKQK
Molecular weight24 kDa including tags
Amino acids1 to 199
TagsHis tag N-Terminus
- Anti-Peroxiredoxin 1/PAG antibody [EPR5433] (ab109498)
- Anti-Peroxiredoxin 1/PAG antibody (ab109766)
- Anti-Peroxiredoxin 1/PAG antibody (ab15571)
- Anti-Peroxiredoxin 1/PAG antibody [13E7] (ab16745)
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Anti-Peroxiredoxin 1/PAG antibody (ab41906)
- Anti-6X His tag® antibody [4D11] (ab5000)
- Anti-Peroxiredoxin 1/PAG antibody (ab59538)
- Anti-Peroxiredoxin 1/PAG antibody (ab79284)
- Anti-6X His tag® antibody - ChIP Grade (ab9108)
Our Abpromise guarantee covers the use of ab167989 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activitySpecific activity: approximately 600-670 pmole/min/µg. Enzymatic activity was confirmed by measuring the remaining peroxide after incubation of Peroxiredoxin 1 and peroxide for 20 min at room temperature. Specific activity is defined as the amount of hydroperoxide that 1 µg of enzyme can reduce at 25°C for 1 minute.
Purity>90% by SDS-PAGE.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituents: 79% Tris HCl, 20% Glycerol
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- Heme binding 23 kDa protein
- Natural killer cell-enhancing factor A
FunctionInvolved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.
Sequence similaritiesBelongs to the ahpC/TSA family.
Contains 1 thioredoxin domain.
modificationsPhosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.
Cellular localizationCytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
- Information by UniProt
ab167989 has not yet been referenced specifically in any publications.