Recombinant Human PH3 protein (ab164181)

Our Abpromise guarantee covers the use of ab164181 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- Early development regulator 3
- Early development regulatory protein 3
- EDR3
- Homolog of polyhomeotic 3
- HPH 3
- hPH3
- PH3
- PHC 3
- Phc3
- PHC3_HUMAN
- Polyhomeotic homolog 3
- Polyhomeotic homolog 3 (Drosophila)
- Polyhomeotic-like protein 3
see all
Function

Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Sequence similarities

Contains 1 FCS-type zinc finger.
Contains 1 SAM (sterile alpha motif) domain.
Post-translational
modifications

Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localization

Nucleus.
Target information above from: UniProt accession Q8NDX5 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human PH3 protein (ab164181)

ab164181 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ab164181 has not yet been referenced specifically in any publications.

Publishing research using ab164181? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"