Recombinant human PI 3 Kinase catalytic subunit gamma/PI3K-gamma protein (ab157600)

Submit a review Submit a question

Overview

Description

  • Nature

    Recombinant

  • Source

    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
      P48736

    • Species

      Human

    • Sequence

      MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRK CKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLY QKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAF QRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHP WVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFT KMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNG EEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHES VFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRR TSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAE SPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFN ADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMP NQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKW GQ QEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQ KLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLF WFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVT LDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGAL AIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQ ILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTV GNTG AFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGI GDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFV MGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTS KEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGI KQGEKHSA

    • Molecular weight

      126 kDa

    • Amino acids

      1 to 1102

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab157600 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    ~4.5nmol/mg/min using phosphatidylinositol as the substrate (lipid kinase activity test).
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity

    > 95 % SDS-PAGE.

  • Form

    Liquid

  • Additional notes

    Previously labelled as PI 3 Kinase catalytic subunit gamma. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    pH: 7.50
    Constituents: 0.005% Magnesium chloride, 0.24% HEPES, 50% Glycerol, 0.58% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • 1 phosphatidylinositol 3 kinase
    • 5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma
    • 5-bisphosphate 3-kinase catalytic subunit gamma isoform
    • p110 gamma
    • p110gamma
    • p120 PI3K
    • p120-PI3K
    • Phosphatidylinositol 3 kinase catalytic 110 kD gamma
    • Phosphatidylinositol 3 kinase gamma, p110 gamma
    • Phosphatidylinositol 3 kinase, catalytic, gamma polypeptide
    • Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit gamma
    • Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit gamma
    • Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit gamma isoform
    • Phosphatidylinositol-4
    • Phosphoinositide 3 kinase catalytic gamma polypeptide
    • Phosphoinositide 3 kinase gamma catalytic subunit
    • PI 3 Kinase catalytic subunit gamma
    • PI3 kinase p110 subunit gamma
    • PI3-kinase subunit gamma
    • PI3CG
    • PI3K
    • PI3K-gamma
    • PI3Kgamma
    • PIK3
    • Pik3cg
    • PK3CG_HUMAN
    • PtdIns-3-kinase subunit gamma
    • PtdIns-3-kinase subunit p110-gamma
    • Serine/threonine protein kinase PIK3CG
    see all

  • Function

    3-phosphorylates the cellular phosphoinositide PtdIns-4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5-triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.

  • Tissue specificity

    Pancreas, skeletal muscle, liver and heart.

  • Pathway

    Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.

  • Sequence similarities

    Belongs to the PI3/PI4-kinase family.
    Contains 1 PI3K/PI4K domain.
  • Information by UniProt

References

ab157600 has not yet been referenced specifically in any publications.

Publishing research using ab157600? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

There are currently no Customer reviews or Questions for ab157600.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up