PI3 Kinase p110 beta: Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
PI3 Kinase p85 beta: Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
SDS-PAGE - PI3 Kinase p110 beta protein (Active) (ab125571)
SDS-PAGE analysis of ab125571. The upper arrow corresponds to PI3 Kinase p110 beta at 111 kDa. The lower arrow corresponds to PI3 Kinase p85 beta at 88 kDa.
Functional Studies - PI3 Kinase p110 beta protein (Active) (ab125571)
The specific activity of ab125571 was determined to be 28 nmol/min/mg.
This product has been referenced in:
Xiang S et al. Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/ß-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer. Int J Oncol51:801-811 (2017).
Read more (PubMed: 28677721) »