Description

  • Product name

    Recombinant Human PICK1 protein
    See all PICK1 proteins and peptides
  • Purity

    > 85 % SDS-PAGE.
    ab202221 was purified using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMFADLDY DIEEDKLGIP TVPGKVTLQK DAQNLIGISI GGGAQYCPCL YIVQVFDNTP AALDGTVAAG DEITGVNGRS IKGKTKVEVA KMIQEVKGEV TIHYNKLQAD PKQGMSLDIV LKKVKHRLVE NMSSGTADAL GLSRAILCND GLVKRLEELE RTAELYKGMT EHTKNLLRAF YELSQTHRAF GDVFSVIGVR EPQPAASEAF VKFADAHRSI EKFGIRLLKT IKPMLTDLNT YLNKAIPDTR LTIKKYLDVK FEYLSYCLKV KEMDDEEYSC IALGEPLYRV STGNYEYRLI LRCRQEARAR FSQMRKDVLE KMELLDQKHV QDIVFQLQRL VSTMSKYYND CYAVLRDADV FPIEVDLAHT TLAYGLNQEE FTDGEEEEEE EDTAAGEPSR DTRGAAGPLD KGGSWCDS
    • Predicted molecular weight

      49 kDa including tags
    • Amino acids

      1 to 415
    • Tags

      His tag N-Terminus
    • Additional sequence information

      NCBI Accession No. NP_001034673.

Specifications

Our Abpromise guarantee covers the use of ab202221 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituents: 69% PBS, 30% Glycerol, 0.02% DTT

General Info

  • Alternative names

    • dJ1039K5
    • MGC15204
    • OTTHUMP00000028509
    • PICK 1
    • Pick1
    • PICK1_HUMAN
    • PRKCA binding protein
    • PRKCA-binding protein
    • PRKCABP
    • Protein interacting with C kinase 1
    • Protein interacting with PRKCA
    • Protein interacting with PRKCA 1
    • Protein kinase C alpha binding protein
    • Protein kinase C-alpha-binding protein
    • Protein that interacts with C kinase 1
    see all
  • Function

    Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.
  • Tissue specificity

    Ubiquitous.
  • Sequence similarities

    Contains 1 AH domain.
    Contains 1 PDZ (DHR) domain.
  • Post-translational
    modifications

    Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
  • Cellular localization

    Cytoplasm > perinuclear region. Cell junction > synapse. Also present at excitatory synapses.
  • Information by UniProt

Images

  • 15% SDS PAGE analysis of ab202221 (3μg).

References

ab202221 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab202221.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up