phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Phosphoinositide 3 Kinase C2 beta
Phosphoinositide 3-Kinase class 2, beta
phosphoinositide-3-kinase, class 2, beta polypeptide
PtdIns 3 kinase C2 beta
PTDINS-3-kinase C2 beta
ptdIns-3-kinase C2 subunit beta
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.
Microsome. Cell membrane. Cytoplasm, cytosol. Nucleus. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.
ab159125 on a 12.5% SDS-PAGE stained with Coomassie Blue.
has not yet been referenced specifically in any publications.
Publishing research using ab159125? Please let us know so that we can cite the reference in this datasheet.
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