• Product name

    Recombinant human Pik3ca + PIK3R1 protein
  • Biological activity

    The Specific activity of ab85833 was determined to be 5147 RLU/min/mg.
  • Expression system

    Baculovirus infected Sf9 cells
  • Protein length

    Full length protein
  • Animal free

  • Nature

    • Species



Our Abpromise guarantee covers the use of ab85833 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Functional Studies


  • Form

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 0.00174% PMSF, 0.82% Sodium phosphate, 0.0308% DTT, 25% Glycerol, 1.74% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • 6330412C2
    • caPI3K
    • GRB1
    • MGC116320
    • MGC142161
    • MGC142163
    • MGC161268
    • OTTMUSP00000023403
    • p110
    • p110alpha
    • p50 alpha
    • p55 alpha
    • p85
    • p85 alpha
    • Phosphatidylinositol 3 kinase associated p85 alpha
    • Phosphatidylinositol 3 kinase catalytic 110 KD alpha
    • Phosphatidylinositol 3 kinase catalytic alpha polypeptide
    • Phosphatidylinositol 3 kinase regulatory 1
    • Phosphatidylinositol 3 kinase regulatory alpha subunit
    • Phosphatidylinositol 3 kinase regulatory subunit alpha
    • Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform
    • Phosphoinositide 3 kinase regulatory subunit 1 (alpha)
    • Phosphoinositide 3 kinase regulatory subunit 1
    • Phosphoinositide 3 kinase regulatory subunit polypeptide 1 (p85 alpha)
    • PI3 kinase p110 subunit alpha
    • PI3 kinase p85 alpha subunit
    • PI3 kinase p85 subunit alpha
    • PI3K
    • PIK3R1
    • PtdIns 3 kinase p110
    • PtdIns 3 kinase p85 alpha
    see all
  • Relevance

    The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Four isoforms of p110 has been found; alpha, beta, gamma, and the delta subunit. The alpha isoform, also known as PI3KCA, is a transforming oncogene that was shown to have activating mutations in nine types of cancers such as colon, brain, breast and stomach.


  • The Specific activity of ab85833 was determined to be 5147 RLU/min/mg.
  • SDS-PAGE showing ab85833 with bands at approximately 111 (Pik3ca) and 86kDa (PIK3R1).


ab85833 has not yet been referenced specifically in any publications.

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