Recombinant Human PIP5K3 protein (ab165864)

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Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MATDDKTSPTLDSANDLPRSPTSPSHLTHFKPLTPDQDEPPFKSAYSSFV NLFRFNKERAEGGQGEQQPLSGSWTSPQLPSRTQSVRSPTPYKKQLNEEL QRRSSALGDLRACTYCRKIALSYAHSTDSNSIGEDLNALSDSACSVSVLD PSEPRTPVGSRKASRNIFLEDDLAWQSLIHPDSSNTPLSTRLVSVQEDAG KSPARNRSASITNLSLDRSGSPMVPSYETSVSPQANRTYVRTETTEDERK ILLDSVQLKDLWKKICHHSSGMEFQDHRYWLRTHPNCIVGKELVNWLIRN GHIATRAQAIAIGQAMVDGRWLDCVSHHDQLFRDEYALYRPLQSTEFSET PSPDSDSVNSVEGHSEPSWFKDIKFDDSDTEQIAEEGDDNLANSASPSKR TSVSSFQSTVDSDSAASISLNVELDNVNFHIKKPSKYPHVPPHPADQKGR R
    • Amino acids
      1 to 451
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab165864 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 1 phosphatidylinositol 3 phosphate 5 kinase
    • 1 phosphatidylinositol 4 phosphate 5 kinase
    • 1-phosphatidylinositol 3-phosphate 5-kinase
    • CFD
    • epididymis luminal protein 37
    • FAB1
    • FAB1, S. cerevisiae, homolog of
    • FYV1_HUMAN
    • FYVE finger containing phosphoinositide kinase
    • FYVE finger-containing phosphoinositide kinase
    • KIAA0981
    • MGC40423
    • p235
    • Phosphatidylinositol 3 phosphate 5 kinase type III
    • Phosphatidylinositol 3 phosphate/phosphatidylinositol 5 kinase type III
    • Phosphatidylinositol 3-phosphate 5-kinase
    • Phosphatidylinositol 3-phosphate 5-kinase type III
    • Phosphatidylinositol 4 phosphate 5 kinase type III
    • Phosphoinositide kinase, FYVE finger containing
    • PIKfyve
    • PIP5K
    • PIP5K3
    • PIPkin III
    • PIPkin-III
    • PtdIns(4)P 5 kinase
    • Type III PIP kinase
    • ZFYVE29
    • Zinc finger, FYVE domain containing 29
    see all
  • Function
    The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.
  • Involvement in disease
    Corneal dystrophy, fleck
  • Sequence similarities
    Contains 1 DEP domain.
    Contains 1 FYVE-type zinc finger.
    Contains 1 PIPK domain.
  • Cellular localization
    Endosome membrane. Mainly associated with membranes of the late endocytic pathway.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human PIP5K3 protein (ab165864)
    SDS-PAGE - Recombinant Human PIP5K3 protein (ab165864)
    ab165864 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab165864 has not yet been referenced specifically in any publications.

Publishing research using ab165864? Please let us know so that we can cite the reference in this datasheet.

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