Overview

  • Product name

    Recombinant human PIP5K3/PIKFYVE protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      110 kDa including tags
    • Amino acids

      1400 to 2098
    • Tags

      GST tag N-Terminus
    • Additional sequence information

      NM_015040

Specifications

Our Abpromise guarantee covers the use of ab207977 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    The specific activity of ab207977 was determined to be 110 nmol/min/mg

  • Applications

    SDS-PAGE

    Functional Studies

  • Purity

    > 70 % Densitometry.

  • Form

    Liquid
  • Additional notes

     This product was previously labelled as PIP5K3

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituents: 0.79% Tris HCl, 0.87% Sodium chloride, 0.31% Glutathione, 0.003% EDTA, 0.004% DTT, 0.002% PMSF, 25% Glycerol

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • 1 phosphatidylinositol 3 phosphate 5 kinase
    • 1 phosphatidylinositol 4 phosphate 5 kinase
    • 1-phosphatidylinositol 3-phosphate 5-kinase
    • CFD
    • epididymis luminal protein 37
    • FAB1
    • FAB1, S. cerevisiae, homolog of
    • FYV1_HUMAN
    • FYVE finger containing phosphoinositide kinase
    • FYVE finger-containing phosphoinositide kinase
    • KIAA0981
    • MGC40423
    • p235
    • Phosphatidylinositol 3 phosphate 5 kinase type III
    • Phosphatidylinositol 3 phosphate/phosphatidylinositol 5 kinase type III
    • Phosphatidylinositol 3-phosphate 5-kinase
    • Phosphatidylinositol 3-phosphate 5-kinase type III
    • Phosphatidylinositol 4 phosphate 5 kinase type III
    • Phosphoinositide kinase, FYVE finger containing
    • PIKfyve
    • PIP5K
    • PIP5K3
    • PIPkin III
    • PIPkin-III
    • PtdIns(4)P 5 kinase
    • Type III PIP kinase
    • ZFYVE29
    • Zinc finger, FYVE domain containing 29
    see all
  • Function

    The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.
  • Involvement in disease

    Corneal dystrophy, fleck
  • Sequence similarities

    Contains 1 DEP domain.
    Contains 1 FYVE-type zinc finger.
    Contains 1 PIPK domain.
  • Cellular localization

    Endosome membrane. Mainly associated with membranes of the late endocytic pathway.
  • Information by UniProt

Images

  • Sample Kinase Activity Plot.

  • SDS-PAGE showing ab207977

References

ab207977 has not yet been referenced specifically in any publications.

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