Recombinant Human Pirh2 protein (denatured) (ab167827)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHHSSGLVPRGSHMGSMAATAREDGASGQERGQRGCEHYDRGC LLKAPCCDKLYTCRLCHDNNEDHQLDRFKVKEVQCINCEKIQHAQQTCEE CSTLFGEYYCDICHLFDKDKKQYHCENCGICRIGPKEDFFHCLKCNLCLA MNLQGRHKCIENVSRQNCPICLEDIHTSRVVAHVLPCGHLLHRTCYEEML KEGYRCPLCMHSALDMTRYWRQLDDEVAQTPMPSEYQNMTVDILCNDCNG RSTVQFHILGMKCKICESYNTAQAGGRRISLDQQ
    • Molecular weight
      33 kDa including tags
    • Amino acids
      1 to 261
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab167827 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 85 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names
    • Androgen receptor N terminal interacting protein
    • Androgen receptor N-terminal-interacting protein
    • ARNIP
    • CH-rich-interacting match with PLAG1
    • CHIMP
    • E3 ubiquitin-protein ligase Pirh2
    • hARNIP
    • hPirh2
    • p53 induced protein with a RING H2 domain
    • p53-induced RING-H2 protein
    • PIRH2E
    • PIRH2F
    • PRO1996
    • RCHY1
    • Ring finger and CHY zinc finger domain containing 1 E3 ubiquitin protein ligase
    • RING finger and CHY zinc finger domain-containing protein 1
    • RING finger protein 199
    • RNF199
    • ZCHY
    • ZFP 363
    • zinc finger CHY type
    • Zinc finger protein 363
    • ZN363_HUMAN
    • ZNF363
    see all
  • Function
    Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Contributes to the regulation of CDKN1B and p53/TP53 levels, and thereby contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Contains 1 CHY-type zinc finger.
    Contains 1 CTCHY-type zinc finger.
    Contains 1 RING-type zinc finger.
  • Post-translational
    modifications
    Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability.
  • Cellular localization
    Nucleus. Nucleus speckle. Cytoplasm.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of 3µg ab167827.

References

ab167827 has not yet been referenced specifically in any publications.

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