Overview

  • Product name

    Recombinant Human PNUTS protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      26 kDa
    • Amino acids

      661 to 929
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127514 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Additional notes

     This product was previously labelled as PPP1R10

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration

General Info

  • Alternative names

    • CAT 53
    • CAT53
    • FB 19
    • FB19
    • FB19 protein
    • HLA-C associated transcript 53
    • MHC class I region proline rich protein CAT53
    • MHC class I region proline-rich protein CAT53
    • p99
    • Phosphatase 1 nuclear targeting subunit
    • Phosphatase nuclear targeting subunit
    • PNUTS
    • PP1 binding protein of 114 kDa
    • PP1 nuclear targeting subunit
    • PP1-binding protein of 114 kDa
    • PP1R10
    • PP1RA_HUMAN
    • ppp1r10
    • Protein FB19
    • Protein phosphatase 1 nuclear targeting subunit
    • Protein phosphatase 1 regulatory (inhibitor) subunit 10
    • Protein phosphatase 1 regulatory subunit 10
    • R111
    • Serine/threonine protein phosphatase 1 regulatory subunit 10
    • Serine/threonine-protein phosphatase 1 regulatory subunit 10
    see all
  • Function

    Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers.
  • Tissue specificity

    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • Sequence similarities

    Contains 1 C3H1-type zinc finger.
    Contains 1 TFIIS N-terminal domain.
  • Post-translational
    modifications

    Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA.
  • Cellular localization

    Nucleus. Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity).
  • Information by UniProt

References

ab127514 has not yet been referenced specifically in any publications.

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