Recombinant Human Podoplanin / gp36 protein (ab132033)

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Overview

Description

  • Nature

    Recombinant

  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
      Q86YL7-3

    • Species

      Human

    • Sequence

      MLTPLGKFSTAKFAVRLPRVWEARAPSLSGAPAPTPPAPPPSRSSRLGLW PRCFLIFPQLRILLLGPQESNNSTGTMWKVSALLFVLGSASLWVLAEGAS TGQPEDDTETTGLEGGVAMPGAEDDVVTPGTSEDRYKSGLTTLVATSVNS VTGIRIEDLPTSESTVHAQEQSPSATASNVATSHSTEKVDGDTQTTVEKD GLSTVTLVGIIVGVLLAIGFIGGIIVVVMRKMSGRYSP

    • Molecular weight

      51 kDa including tags

    • Amino acids

      1 to 238

    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab132033 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

    ELISA

  • Form

    Liquid

  • Additional notes

    Protein concentration is above or equal to 0.05 µg/µl.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • Aggrus
    • Glycoprotein 36 KD
    • Glycoprotein 36
    • gp 36
    • GP 38
    • GP 40
    • gp36
    • GP38
    • GP40
    • HT1A 1
    • HT1A1
    • hT1alpha 1
    • hT1alpha 2
    • hT1alpha1
    • hT1alpha2
    • Lung type I cell membrane associated glycoprotein
    • Lung type I cell membrane associated glycoprotein isoform a
    • Lung type I cell membrane associated glycoprotein T1A 2
    • OTS 8
    • OTS8
    • OTTHUMP00000009640
    • OTTHUMP00000044504
    • PA2.26
    • PA2.26 antigen
    • Pdpn
    • PDPN_HUMAN
    • Podoplanin
    • PSEC0003
    • PSEC0025
    • T1 alpha
    • T1 ALPHA GENE
    • T1-alpha
    • T1A
    • T1A 2
    • TI1A
    • TIA 2
    • TIA2
    see all

  • Function

    May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.

  • Tissue specificity

    Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.

  • Sequence similarities

    Belongs to the podoplanin family.

  • Post-translational
    modifications

    Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.
    The N-terminus is blocked.

  • Cellular localization

    Membrane. Cell projection > filopodium membrane. Cell projection > lamellipodium membrane. Cell projection > microvillus membrane. Cell projection > ruffle membrane. Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human Podoplanin / gp36 protein (ab132033)
    SDS-PAGE - Recombinant Human Podoplanin / gp36 protein (ab132033)
    12.5% SDS-PAGE stained with Coomassie Blue showing ab132033 at approximately 51.3 kDa.

References

ab132033 has not yet been referenced specifically in any publications.

Publishing research using ab132033? Please let us know so that we can cite the reference in this datasheet.

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