Recombinant Human POGLUT1 protein (His tag) (ab219279)

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Description

  • Product name

    Recombinant Human POGLUT1 protein (His tag)

  • Purity

    > 90 % SDS-PAGE.
    ab219279 was purified by using conventional chromatography techniques.

  • Endotoxin level

    < 1.000 Eu/µg

  • Expression system

    Baculovirus infected insect cells

  • Accession

    Q8NBL1

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      RQKESGSKWK VFIDQINRSL ENYEPCSSQN CSCYHGVIEE DLTPFRGGIS RKMMAEVVRR KLGTHYQITK NRLYRENDCM FPSRCSGVEH FILEVIGRLP DMEMVINVRD YPQVPKWMEP AIPVFSFSKT SEYHDIMYPA WTFWEGGPAV WPIYPTGLGR WDLFREDLVR SAAQWPWKKK NSTAYFRGSR TSPERDPLIL LSRKNPKLVD AEYTKNQAWK SMKDTLGKPA AKDVHLVDHC KYKYLFNFRG VAASFRFKHL FLCGSLVFHV GDEWLEFFYP QLKPWVHYIP VKTDLSNVQE LLQFVKANDD VAQEIAERGS QFIRNHLQMD DITCYWENLL SEYSKFLSYN VTRRKGYDQI IPKMLKTELL EHHHHHH

    • Predicted molecular weight

      45 kDa including tags

    • Amino acids

      24 to 392

    • Tags

      His tag C-Terminus

    • Additional sequence information

      Corresponding to the mature protein without initial signal peptide.

Specifications

Our Abpromise guarantee covers the use of ab219279 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid

  • Additional notes

    Previously labelled as KTEL1.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.4
    Constituents: 90% PBS, 10% Glycerol

General Info

  • Alternative names

    • C3orf9
    • CAP10 like 46 kDa protein
    • CAP10 like protein, 46 kDa
    • CAP10-like 46 kDa protein
    • CLP46
    • hCLP46
    • hRumi
    • KDELC family like 1
    • KDELCL1
    • KTEL (Lys Tyr Glu Leu) containing 1
    • KTEL motif containing protein 1
    • KTEL motif-containing protein 1
    • KTEL1
    • KTELC1
    • MDS010
    • MDSRP
    • Myelodysplastic syndromes relative protein
    • O-glucosyltransferase rumi homolog
    • PGLT1_HUMAN
    • Poglut1
    • protein O glucosyltransferase 1
    • Protein O-glucosyltransferase 1
    • Protein O-xylosyltransferase
    • Rumi
    • x 010 protein
    see all

  • Function

    Dual specificity glycosyltransferase. Catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to EGF repeats, such as those found in F7, F9 and NOTCH2, on the consensus sequence C-X-S-X-P-C. Positively regulates Notch signaling without affecting Notch ligand binding.

  • Tissue specificity

    Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. Expressed in the epidermis, especially in the upper parts, stratum spinosum and stratum granulosum (at protein level).

  • Pathway

    Protein modification; protein glycosylation.

  • Involvement in disease

    Dowling-Degos disease 4

  • Sequence similarities

    Belongs to the glycosyltransferase 90 family.

  • Cellular localization

    Endoplasmic reticulum lumen.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human POGLUT1 protein (His tag) (ab219279)
    SDS-PAGE - Recombinant Human POGLUT1 protein (His tag) (ab219279)

    15% SDS-PAGE - Recombinant Human POGLUT1 protein (His tag) (ab219279) at 3 μg.

References

ab219279 has not yet been referenced specifically in any publications.

Publishing research using ab219279? Please let us know so that we can cite the reference in this datasheet.

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