Description

  • Product name

    Recombinant Human POLR1C protein
  • Purity

    > 80 % SDS-PAGE.
    ab180317 is purified using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGS MAASQAVEEM RSRVVLGEFG VRNVHTTDFP GNYSGYDDAW DQDRFEKNFR VDVVHMDENS LEFDMVGIDA AIANAFRRIL LAEVPTMAVE KVLVYNNTSI VQDEILAHRL GLIPIHADPR LFEYRNQGDE EGTEIDTLQF RLQVRCTRNP HAAKDSSDPN ELYVNHKVYT RHMTWIPLGN QADLFPEGTI RPVHDDILIA QLRPGQEIDL LMHCVKGIGK DHAKFSPVAT ASYRLLPDIT LLEPVEGEAA EELSRCFSPG VIEVQEVQGK KVARVANPRL DTFSREIFRN EKLKKVVRLA RVRDHYIFSV ESTGVLPPDV LVSEAIKVLM GKCRRFLDEL DAVQMD
    • Predicted molecular weight

      42 kDa including tags
    • Amino acids

      1 to 346
    • Tags

      His tag N-Terminus
    • Additional sequence information

      NP_976035.

Specifications

Our Abpromise guarantee covers the use of ab180317 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8
    Constituents: 20% Glycerol, 0.02% DTT, 0.88% Sodium chloride, 0.32% Tris HCl

General Info

  • Alternative names

    • 40kDa
    • AA409007
    • AA959927
    • Ac2-127
    • AC40
    • AL024089
    • DNA directed RNA polymerase I subunit C
    • DNA directed RNA polymerases I and III 40 kDa polypeptide
    • DNA directed RNA polymerases I and III subunit RPAC1
    • DNA-directed RNA polymerase I subunit C
    • DNA-directed RNA polymerases I and III 40 kDa polypeptide
    • DNA-directed RNA polymerases I and III subunit RPAC1
    • MGC105583
    • MGC161175
    • POLR1C
    • POLR1E
    • Polymerase (RNA) I polypeptide C, 30kDa
    • RNA polymerase 1 1
    • RNA polymerase I subunit C
    • RNA polymerases I and III subunit AC1
    • RP3-337H4.4
    • RPA39
    • RPA40
    • RPA5
    • RPAC1
    • RPAC1_HUMAN
    • RPC40
    • Rpo1 1
    • TCS3
    see all
  • Function

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
  • Involvement in disease

    Treacher Collins syndrome 3 (TCS3) [MIM:248390]: A form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities

    Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab180317 (3µg)

References

ab180317 has not yet been referenced specifically in any publications.

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