The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
DNA directed RNA polymerase III subunit K
DNA directed RNA polymerase III subunit RPC10
DNA directed RNA polymerases III 12.5 kDa polypeptide
DNA-directed RNA polymerase III subunit K
DNA-directed RNA polymerase III subunit RPC10
Polymerase (RNA) III (DNA directed) polypeptide K
Polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
RNA polymerase III 12.5 kDa subunit
RNA polymerase III subunit (hRPC11)
RNA polymerase III subunit C10
RNA polymerase III subunit C11
RNA polymerase III subunit CII
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. Contains 1 TFIIS-type zinc finger.