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Recombinant Human PON1 protein (ab53376)

  • Datasheet
  • SDS
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SDS-PAGE - Recombinant Human PON1 protein (ab53376)
  • Western blot - Recombinant Human PON1 protein (ab53376)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Suitable for: WB, SDS-PAGE

Description

  • Product name

    Recombinant Human PON1 protein
    See all PON1 proteins and peptides
  • Purity

    > 95 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human

Associated products

  • Related Products

    • Anti-PON1 antibody [17A12] (ab24261)

Specifications

Our Abpromise guarantee covers the use of ab53376 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.242% Tris, 50% Glycerol

General Info

  • Alternative names

    • A esterase 1
    • A-esterase 1
    • Aromatic esterase 1
    • Arylesterase 1
    • Arylesterase B type
    • ESA
    • Esterase A
    • K 45
    • K-45
    • MVCD5
    • Paraoxonase
    • Paraoxonase 1
    • Paraoxonase B type
    • Paraoxonase, plasma
    • Paraoxonase1
    • PON
    • PON 1
    • PON1
    • PON1_HUMAN
    • Serum aryldiakylphosphatase
    • Serum aryldialkylphosphatase 1
    • Serum paraoxonase/arylesterase 1
    see all
  • Function

    Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
  • Tissue specificity

    Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
  • Involvement in disease

    Genetic variation in PON1 is associated with susceptibility to microvascular complications of diabetes type 5 (MVCD5) [MIM:612633]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Homozygosity for the Leu-54 allele is strongly associated with the development of retinal disease in diabetic patients.
  • Sequence similarities

    Belongs to the paraoxonase family.
  • Post-translational
    modifications

    Glycosylated.
    The signal sequence is not cleaved.
    Present in two forms, form B contains a disulfide bond, form A does not.
  • Cellular localization

    Secreted > extracellular space.
  • Target information above from: UniProt accession P27169 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Images

  • SDS-PAGE - Recombinant Human PON1 protein (ab53376)
    SDS-PAGE - Recombinant Human PON1 protein (ab53376)
    SDS Page analysis of ab53376.
  • Western blot - Recombinant Human PON1 protein (ab53376)
    Western blot - Recombinant Human PON1 protein (ab53376)

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab53376? Please let us know so that we can cite the reference in this datasheet.

ab53376 has not yet been referenced specifically in any publications.

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