Recombinant human PPIG protein (ab167986)

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SDS-PAGE - Recombinant human PPIG protein (ab167986)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 95% SDS-PAGE
    • Active: Yes
    • Tags: His tag N-Terminus
    • Suitable for: SDS-PAGE, Functional Studies

    Description

    • Product name

      Recombinant human PPIG protein

    • Biological activity

      Specific activity is > 200 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1 µmole of Suc-AAFP-pNA per minute at 25°C in Tris HCl pH8.0 using chymotrypsin.

    • Purity

      > 95 % SDS-PAGE.

    • Expression system

      Escherichia coli

    • Accession

      Q13427

    • Protein length

      Protein fragment

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MGSSHHHHHH SSGLVPRGSH MGIKVQRPRC FFDIAINNQP AGRVVFELFS DVCPKTCENF RCLCTGEKGT GKSTQKPLHY KSCLFHRVVK DFMVQGGDFS EGNGRGGESI YGGFFEDESF AVKHNKEFLL SMANRGKDTN GSQFFITTKP TPHLDGHHVV FGQVISGQEV VREIENQKTD AASKPFAEVR ILSCG

      • Predicted molecular weight

        22 kDa including tags

      • Amino acids

        1 to 175

      • Tags

        His tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab167986 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Functional Studies

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      pH: 8.00
      Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    General Info

    • Alternative names

      • CARS cyclophilin
      • CARS Cyp
      • CARS-cyclophilin
      • CARS-Cyp
      • CASP 10
      • CASP10
      • Clk associating RS cyclophilin
      • Clk-associating RS-cyclophilin
      • Cyclophilin G
      • CyclophilinG
      • CYP
      • MGC133241
      • Peptidyl prolyl cis trans isomerase G
      • Peptidyl prolyl isomerase G
      • Peptidyl prolyl isomerase G (cyclophilin G)
      • Peptidyl-prolyl cis-trans isomerase G
      • Peptidyl-prolyl isomerase G
      • Peptidylprolyl isomerase G
      • Peptidylprolyl isomerase G (cyclophilin G)
      • PPIase G
      • Ppig
      • PPIG_HUMAN
      • Rotamase G
      • RotamaseG
      • SCAF10
      • SR cyclophilin
      • SR cyp
      • SR related CTD associated factor 10
      • SR-cyclophilin
      • SR-cyp
      • SRcyp
      see all

    • Function

      PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.

    • Tissue specificity

      Ubiquitous.

    • Sequence similarities

      Contains 1 PPIase cyclophilin-type domain.

    • Domain

      The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II.

    • Post-translational
      modifications

      Phosphorylated upon DNA damage, probably by ATM or ATR.

    • Cellular localization

      Nucleus matrix. Nucleus speckle. Colocalizes with RNA splicing factors at nuclear speckles.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant human PPIG protein (ab167986)
      SDS-PAGE - Recombinant human PPIG protein (ab167986)
      15% SDS-PAGE analysis of ab167986 (3 µg).

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab167986? Please let us know so that we can cite the reference in this datasheet.

    ab167986 has not yet been referenced specifically in any publications.

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