Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
      Q13427
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGIKVQRPRC FFDIAINNQP AGRVVFELFS DVCPKTCENF RCLCTGEKGT GKSTQKPLHY KSCLFHRVVK DFMVQGGDFS EGNGRGGESI YGGFFEDESF AVKHNKEFLL SMANRGKDTN GSQFFITTKP TPHLDGHHVV FGQVISGQEV VREIENQKTD AASKPFAEVR ILSCG
    • Molecular weight
      22 kDa including tags
    • Amino acids
      1 to 175
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab167986 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Specific activity is > 200 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1 µmole of Suc-AAFP-pNA per minute at 25°C in Tris HCl pH8.0 using chymotrypsin.
  • Applications

    SDS-PAGE

    Functional Studies

  • Purity
    >95% by SDS-PAGE .

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • CARS cyclophilin
    • CARS Cyp
    • CARS-cyclophilin
    • CARS-Cyp
    • CASP 10
    • CASP10
    • Clk associating RS cyclophilin
    • Clk-associating RS-cyclophilin
    • Cyclophilin G
    • CyclophilinG
    • CYP
    • MGC133241
    • Peptidyl prolyl cis trans isomerase G
    • Peptidyl prolyl isomerase G
    • Peptidyl prolyl isomerase G (cyclophilin G)
    • Peptidyl-prolyl cis-trans isomerase G
    • Peptidyl-prolyl isomerase G
    • Peptidylprolyl isomerase G
    • Peptidylprolyl isomerase G (cyclophilin G)
    • PPIase G
    • Ppig
    • PPIG_HUMAN
    • Rotamase G
    • RotamaseG
    • SCAF10
    • SR cyclophilin
    • SR cyp
    • SR related CTD associated factor 10
    • SR-cyclophilin
    • SR-cyp
    • SRcyp
    see all
  • Function
    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Contains 1 PPIase cyclophilin-type domain.
  • Domain
    The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus matrix. Nucleus speckle. Colocalizes with RNA splicing factors at nuclear speckles.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant human PPIG protein (ab167986)
    SDS-PAGE - Recombinant human PPIG protein (ab167986)
    15% SDS-PAGE analysis of ab167986 (3 µg).

References

ab167986 has not yet been referenced specifically in any publications.

Publishing research using ab167986? Please let us know so that we can cite the reference in this datasheet.

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