Recombinant human PPIG protein (ab167986)
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- References
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Overview
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Product nameRecombinant human PPIG protein
See all PPIG proteins and peptides -
Protein lengthProtein fragment
Description
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NatureRecombinant
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SourceEscherichia coli
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Amino Acid Sequence
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Accession
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SpeciesHuman
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SequenceMGSSHHHHHH SSGLVPRGSH MGIKVQRPRC FFDIAINNQP AGRVVFELFS DVCPKTCENF RCLCTGEKGT GKSTQKPLHY KSCLFHRVVK DFMVQGGDFS EGNGRGGESI YGGFFEDESF AVKHNKEFLL SMANRGKDTN GSQFFITTKP TPHLDGHHVV FGQVISGQEV VREIENQKTD AASKPFAEVR ILSCG
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Molecular weight22 kDa including tags
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Amino acids1 to 175
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TagsHis tag N-Terminus
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab167986 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Biological activitySpecific activity is > 200 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1 µmole of Suc-AAFP-pNA per minute at 25°C in Tris HCl pH8.0 using chymotrypsin.
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Applications
SDS-PAGE
Functional Studies
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Purity>95% by SDS-PAGE .
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FormLiquid
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.58% Sodium chlorideThis product is an active protein and may elicit a biological response in vivo, handle with caution.
General Info
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Alternative names
- CARS cyclophilin
- CARS Cyp
- CARS-cyclophilin
see all -
FunctionPPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.
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Tissue specificityUbiquitous.
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Sequence similaritiesContains 1 PPIase cyclophilin-type domain.
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DomainThe RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II.
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Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localizationNucleus matrix. Nucleus speckle. Colocalizes with RNA splicing factors at nuclear speckles.
- Information by UniProt
Images
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SDS-PAGE - Recombinant human PPIG protein (ab167986)15% SDS-PAGE analysis of ab167986 (3 µg).
Datasheets and documents
References
ab167986 has not yet been referenced specifically in any publications.
