Overview

Description

  • Nature

    Recombinant
  • Source

    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      105 kDa including tags
    • Amino acids

      1 to 382

Associated products

Specifications

Our Abpromise guarantee covers the use of ab128560 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Phosphatase Activity

    SDS-PAGE

  • Purity

    > 70 % Densitometry.

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • Protein phosphatase 2C isoform alpha
    • EC 3.1.3.16
    • FLJ42306
    • IA
    • MGC9201
    • Mpp alpha
    • PP2C alpha
    • PP2C-alpha
    • PP2CA
    • PP2Calpha
    • PPM 1A
    • PPM1A
    • PPM1A_HUMAN
    • PPPM1A
    • Protein phosphatase 1A
    • Protein phosphatase 1A (formerly 2C) magnesium dependent alpha isoform
    • Protein phosphatase 1A magnesium dependent alpha
    • Protein phosphatase 2C alpha
    • Protein phosphatase 2C alpha isoform
    • Protein phosphatase 2C isoform alpha
    • Protein phosphatase IA
    • Protein phosphatase, Mg2+/Mn2+ dependent, 1A
    see all
  • Function

    Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.
  • Sequence similarities

    Belongs to the PP2C family.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • The specific activity of ab128560 was determined to be 1200 nmol/min/mg.
  • SDS-PAGE showing ab128560 at approximately 105 kDa.

References

ab128560 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab128560.
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