Overview

Description

  • Nature

    Recombinant
  • Source

    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      62 kDa including tags
    • Amino acids

      1 to 330

Associated products

Specifications

Our Abpromise guarantee covers the use of ab128559 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    The specific activity of ab128559 was determined to be 228 nmol/min/mg.
  • Applications

    Western blot

    Phosphatase Activity

  • Purity

    > 75 % Densitometry.

  • Form

    Liquid
  • Additional notes

     This product was previously labelled as PPP1A

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.005% DTT, 0.79% Tris HCl, 0.003% EDTA, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • Alpha isoform serine threonine protein phosphatase PP1alpha 1 catalytic subunit
    • Catalytic subunit
    • EC 3.1.3.16
    • MGC15877
    • MGC1674
    • PP 1A
    • PP-1A
    • PP1A
    • PP1A_HUMAN
    • PP1alpha
    • PP2C ALPHA
    • PP2CA
    • Ppp1ca
    • Protein Phosphatase 2C Alpha Isoform
    • Serine threonine protein phosphatase PP1 alpha catalytic subunit
    • Serine threonine protein phosphatase PP1 alpha catalytic subunit protein phosphatase 1
    • Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    see all
  • Function

    Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
  • Sequence similarities

    Belongs to the PPP phosphatase family. PP-1 subfamily.
  • Cellular localization

    Cytoplasm. Nucleus. Nucleus > nucleoplasm. Nucleus > nucleolus. Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
  • Information by UniProt

Images

  • The specific activity of ab128559 was determined to be 228 nmol/min/mg.
  • SDS-PAGE showing ab128559 at approximately 62 kDa.

References

ab128559 has not yet been referenced specifically in any publications.

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